Norflex and Metoclopramide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Metoclopramide (metoclopramide hydrochloride). Common drug interactions include nasopharyngitis among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Metoclopramide. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is often used in nausea. eHealthMe is studying from 81,263 Metoclopramide users. Check the latest studies of Metoclopramide.



On Jul, 16, 2026

14 people who take Norflex and Metoclopramide together, and have interactions are studied.

Norflex and Metoclopramide drug interactions.

What are the common drug interactions of Norflex and Metoclopramide, by gender? *:

female:

  1. Nasopharyngitis (inflammation of the nasopharynx)
  2. Abdominal pain
  3. Activities of daily living impaired
  4. Anaemia (lack of blood)
  5. Arthralgia (joint pain)
  6. Asthenia (weakness)
  7. Asthma
  8. Azotaemia (excess of urea or other nitrogenous compounds in the blood)
  9. Cellulitis (infection under the skin)
  10. Conjunctivitis (pink eye)

male:

  1. Pain
  2. Dizziness
  3. Irritable bowel syndrome
  4. Joint stiffness
  5. Joint swelling
  6. Oral pain
  7. Stress
  8. Dystonia (abnormal muscle tone)
  9. Injury
  10. Adverse drug reaction

What are the common drug interactions of Norflex and Metoclopramide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abdominal discomfort
  2. Abdominal distension
  3. Activities of daily living impaired
  4. Akathisia (a movement disorder characterized by a feeling of inner restlessness)
  5. Anxiety
  6. Asthenia (weakness)
  7. Bruxism (habitual grinding of the teeth, typically during sleep)
  8. Deformity (disfigurement)
  9. Depression
  10. Dyskinesia (abnormality or impairment of voluntary movement)

30-39:

n/a

40-49:

  1. Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
  2. Abdominal pain
  3. Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
  4. Anxiety
  5. Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)
  6. Arthralgia (joint pain)
  7. Asthma
  8. Astigmatism (refractive error of the eye in which parallel rays of light from an external source do not converge on a single focal point on the retina)
  9. Azotaemia (excess of urea or other nitrogenous compounds in the blood)
  10. Blood glucose decreased

50-59:

  1. Dyspepsia (indigestion)
  2. Dysphonia (speech disorder attributable to a disorder of phonation)
  3. Erectile dysfunction
  4. Gingival pain (gum pain)
  5. Haematocrit decreased
  6. Haemoglobin decreased
  7. Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
  8. Incoherent (talking in a confused and unclear way)
  9. Laryngospasm (an uncontrolled/involuntary muscular contraction of larynx)
  10. Loss of consciousness

60+:

  1. Fatigue (feeling of tiredness)
  2. Anaemia (lack of blood)
  3. Diarrhoea
  4. Drug hypersensitivity
  5. Drug ineffective
  6. Drug intolerance (drug sensitivity)
  7. Fibromyalgia (a long-term condition which causes pain all over the body)
  8. Headache (pain in head)
  9. Herpes zoster
  10. Infection

What are the existing conditions these people have? *

  1. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 35.71%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 28.57%
  3. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 21.43%
  4. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 14.29%
  5. Pulmonary Congestion (congestion in the lungs): 1 person, 7.14%
  6. Impaired Gastric Emptying: 1 person, 7.14%
  7. Cough: 1 person, 7.14%
  8. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Norflex and Metoclopramide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Metoclopramide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Norflex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metoclopramide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on orphenadrine citrate and metoclopramide hydrochloride (the active ingredients of Norflex and Metoclopramide, respectively), and Norflex and Metoclopramide (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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