Norflex and Nystatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Nystatin (nystatin). Common drug interactions include drug level increased among females and tremor among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Nystatin. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Nystatin?

Nystatin has active ingredients of nystatin. It is often used in thrush. eHealthMe is studying from 33,568 Nystatin users. Check the latest studies of Nystatin.



On Aug, 08, 2026

34 people who take Norflex and Nystatin together, and have interactions are studied.

Norflex and Nystatin drug interactions.

What are the common drug interactions of Norflex and Nystatin, by gender? *:

female:

  1. Drug level increased
  2. Gait disturbance
  3. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  4. Headache (pain in head)
  5. Neuropathy peripheral (surface nerve damage)
  6. Pain in extremity
  7. Abscess (pus)
  8. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  9. Asthma
  10. Erythema (redness of the skin)

male:

  1. Tremor (trembling or shaking movements in one or more parts of your body)
  2. Abdominal pain
  3. Oesophageal ulcer (ulcer of oesophagus)
  4. Pain
  5. Pain in extremity
  6. Abdominal discomfort
  7. Abscess jaw (tooth abscess or root abscess)
  8. Actinomycosis (infection that causes sores, or abscesses)
  9. Anaemia (lack of blood)
  10. Aortic calcification (aortic calcification sign of heart valve disease)

What are the common drug interactions of Norflex and Nystatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Drug level increased

50-59:

  1. Gait disturbance
  2. Headache (pain in head)
  3. Tenderness (pain or discomfort when an affected area is touched)
  4. Tremor (trembling or shaking movements in one or more parts of your body)
  5. Abdominal discomfort
  6. Actinomycosis (infection that causes sores, or abscesses)
  7. Anaemia (lack of blood)
  8. Arthralgia (joint pain)
  9. Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
  10. Beta haemolytic streptococcal infection (infection with streptococcus pyogenes, a beta-haemolytic bacterium cause mild to moderately severe respiratory tract, skin, and soft tissue)

60+:

  1. Pain
  2. Depression
  3. Pain in extremity
  4. Peripheral swelling
  5. Pulmonary embolism (blockage of the main artery of the lung)
  6. Abasia (inability to walk)
  7. Abscess (pus)
  8. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  9. Angina pectoris (chest pain due to ischemia of the heart muscle)
  10. Angiopathy (generic term for a disease of the blood vessels)

What are the existing conditions these people have? *

  1. High Blood Pressure: 5 people, 14.71%
  2. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 8.82%
  3. Psoriasis (immune-mediated disease that affects the skin): 3 people, 8.82%
  4. Ovarian Cancer (cancer of ovary): 3 people, 8.82%
  5. Immunodeficiency Common Variable: 3 people, 8.82%
  6. Heart Rate Irregular: 3 people, 8.82%
  7. Gout (uric acid crystals building up in the body): 3 people, 8.82%
  8. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.88%
  9. Pulmonary Embolism (blockage of the main artery of the lung): 2 people, 5.88%
  10. Depression: 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Norflex and Nystatin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Norflex and Nystatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nystatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Norflex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nystatin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on orphenadrine citrate and nystatin (the active ingredients of Norflex and Nystatin, respectively), and Norflex and Nystatin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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