Norflex and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include arthritis among females and dysuria among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Spiriva. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

On Jul, 15, 2026

41 people who take Norflex and Spiriva together, and have interactions are studied.

What are the common drug interactions of Norflex and Spiriva, by gender? *:

female:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthralgia (joint pain)
Hypotension (abnormally low blood pressure)
Pain in extremity
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Anaemia (lack of blood)
Dysphagia (a condition in which swallowing is difficult or painful)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Diarrhoea

male:

Dysuria (painful or difficult urination)
Fall
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nephrolithiasis (calculi in the kidneys)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pulmonary oedema (fluid accumulation in the lungs)

What are the common drug interactions of Norflex and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hypertension (high blood pressure)
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Weight increased

40-49:

Cough
Dyspnoea (difficult or laboured respiration)
Fall
Anxiety
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Diarrhoea
Insomnia (sleeplessness)
Vomiting
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

50-59:

Bone pain
Breast tenderness
Cardiac arrest
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cerumen impaction
Decreased interest
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dysphagia (a condition in which swallowing is difficult or painful)
Ear pain
Epicondylitis (tennis elbow)

60+:

Pain
Dyspnoea (difficult or laboured respiration)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arrhythmia (irregular heartbeat)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood creatinine increased
Blood glucose increased

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 31.71%
Pain: 5 people, 12.20%
Neuralgia (pain in one or more nerves): 4 people, 9.76%
Migraine (headache): 3 people, 7.32%
Haemodilution (increase in the volume of plasma in relation to red blood cells): 3 people, 7.32%
Fatigue (feeling of tiredness): 3 people, 7.32%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 3 people, 7.32%
Constipation: 3 people, 7.32%
Cardiac Disorder: 3 people, 7.32%
Bronchial Disorder: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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