Norgesic and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norgesic (aspirin; caffeine; orphenadrine citrate) and Metformin (metformin hydrochloride). Common drug interactions include uterine cancer among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Norgesic and Metformin. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Norgesic?

Norgesic has active ingredients of aspirin; caffeine; orphenadrine citrate. eHealthMe is studying from 330 Norgesic users. Check the latest studies of Norgesic.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 27, 2026

11 people who take Norgesic and Metformin together, and have interactions are studied.

Norgesic and Metformin drug interactions.

What are the common drug interactions of Norgesic and Metformin, by gender? *:

female:

Uterine cancer
Vaginal haemorrhage (vaginal bleeding)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Anuria (failure of the kidneys to produce urine)
Death
Emotional distress
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)

male:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Bilirubin conjugated increased
Death
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the common drug interactions of Norgesic and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acute myocardial infarction (acute heart attack)
Chest pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Dizziness
Dyspnoea exertional (breathlessness or shortness of breath)
Uterine cancer
Vaginal haemorrhage (vaginal bleeding)
Syncope (loss of consciousness with an inability to maintain postural tone)

50-59:

Death
Dizziness
Dyspnoea exertional (breathlessness or shortness of breath)
Emotional distress
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Pulmonary congestion (congestion in the lungs)
Uterine cancer
Vaginal haemorrhage (vaginal bleeding)
Acute myocardial infarction (acute heart attack)

60+:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Bilirubin conjugated increased

What are the existing conditions these people have? *

Type 2 Diabetes: 2 people, 18.18%
High Blood Cholesterol: 2 people, 18.18%
Constipation: 2 people, 18.18%
Pain: 1 person, 9.09%
Multiple Myeloma (cancer of the plasma cells): 1 person, 9.09%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 9.09%
Itching: 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Hepatitis C: 1 person, 9.09%
Dyslipidaemia (abnormal amount of lipids): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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