Norpace and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norpace (disopyramide phosphate) and Premarin (estrogens, conjugated). Common drug interactions include bradycardia among females.

The phase IV clinical study analyzes what interactions people have when they take Norpace and Premarin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Norpace?

Norpace has active ingredients of disopyramide phosphate. eHealthMe is studying from 1,179 Norpace users. Check the latest studies of Norpace.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 15, 2026

21 people who take Norpace and Premarin together, and have interactions are studied.

What are the common drug interactions of Norpace and Premarin, by gender? *:

female:

Bradycardia (abnormally slow heart action)
Syncope (loss of consciousness with an inability to maintain postural tone)
Hypoaesthesia (reduced sense of touch or sensation)
Left ventricular failure (left ventricle fails to contract forcefully)
Nausea (feeling of having an urge to vomit)
Nodal arrhythmia (an irregular heart beat originating from within the atrioventricular node)
Pain in limb
Palpitations (feelings or sensations that your heart is pounding or racing)
Peripheral neuropathy (damage to nerves of the peripheral nervous system)
Sweating increased (excess sweating)

male:

n/a

What are the common drug interactions of Norpace and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cardiomyopathy (weakening of the heart muscle)
Chest pain
Left ventricular failure (left ventricle fails to contract forcefully)
Palpitations (feelings or sensations that your heart is pounding or racing)
Echocardiogram abnormal
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Ventricular extrasystoles (premature cardiac contraction)

60+:

Bradycardia (abnormally slow heart action)
Syncope (loss of consciousness with an inability to maintain postural tone)
Pain in limb
Peripheral neuropathy (damage to nerves of the peripheral nervous system)
Sweating increased (excess sweating)
Abdominal discomfort
Abdominal pain upper
Angioneurotic oedema (swelling that occurs just beneath the surface of the skin or mucous membranes)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Breast lump (localized swelling that feels different from the surrounding breast tissue)

* Approximation only. Some reports may have incomplete information.

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