Methotrexate and Black cohosh drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Black cohosh (black cohosh). Common drug interactions include pain among females.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Black cohosh. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Black cohosh?

Black cohosh has active ingredients of black cohosh. It is often used in menopause. eHealthMe is studying from 1,382 Black cohosh users. Check the latest studies of Black cohosh.

On Jul, 15, 2026

50 people who take Methotrexate and Black cohosh together, and have interactions are studied.

Methotrexate and Black cohosh drug interactions.

What are the common drug interactions of Methotrexate and Black Cohosh, by gender? *:

female:

Pain
Pain in extremity
Chronic kidney disease
Decreased appetite
Exostosis (formation of new bone on the surface of a bone)
Fall
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Phantom pain

male:

n/a

What are the common drug interactions of Methotrexate and Black Cohosh, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Immune system disorder
Memory impairment
Myositis (inflammation of the muscles)
Pain
Sleep disorder due to general medical condition, insomnia type (a conditions that prevent a person from getting restful sleep due to mental condition of not getting sleep)
Vitamin d deficiency
Crying
Dehydration (dryness resulting from the removal of water)
Foot fracture
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

50-59:

Pain
Pain in extremity
Fatigue (feeling of tiredness)
Productive cough
Pyrexia (fever)
Arthralgia (joint pain)
Asthenia (weakness)
Chills (felling of cold)
Decreased appetite
Diarrhoea

60+:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Pain in extremity
Eye disorder
Fall
Fatigue (feeling of tiredness)
Head injury
Heart rate increased
Hypersensitivity
Injection site haemorrhage (bleeding from injection site)
Injection site urticaria (rash of round, red welts on the skin at injection site)

What are the existing conditions these people have? *

Hot Flush (sudden feelings of heat): 13 people, 26.00%
High Blood Pressure: 12 people, 24.00%
Depression: 7 people, 14.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 14.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 14.00%
Pain: 6 people, 12.00%
Hypersensitivity: 5 people, 10.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 10.00%
Stress And Anxiety: 5 people, 10.00%
Calcium Deficiency (lack of calcium): 4 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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