Northera and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Northera (droxidopa) and Ibu (ibuprofen). Common drug interactions include fall among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Northera and Ibu. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Northera?

Northera has active ingredients of droxidopa. eHealthMe is studying from 22,874 Northera users. Check the latest studies of Northera.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

On Jul, 20, 2026

92 people who take Northera and Ibu together, and have interactions are studied.

What are the common drug interactions of Northera and Ibu, by gender? *:

female:

Fall
Cardiac failure congestive
Dehydration (dryness resulting from the removal of water)
Night sweats (sweating in night)
Depression
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary tract infection
Cholecystitis (infection of gallbladder)
Drug intolerance (drug sensitivity)

male:

Hypotension (abnormally low blood pressure)
Dizziness
Syncope (loss of consciousness with an inability to maintain postural tone)
Fatigue (feeling of tiredness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Dehydration (dryness resulting from the removal of water)
Drug intolerance (drug sensitivity)
Heart rate increased
Loss of consciousness
Memory impairment

What are the common drug interactions of Northera and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infusion site pain
Pain in extremity
Urinary tract infection

20-29:

Dizziness
Dyspnoea (difficult or laboured respiration)
Migraine (headache)
Therapeutic response decreased (less preventive response)

30-39:

Nausea (feeling of having an urge to vomit)
Vomiting
Dizziness
Diarrhoea
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Migraine (headache)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

40-49:

Malaise (a feeling of general discomfort or uneasiness)
Gait disturbance
Labile blood pressure (wildly fluctuating blood pressure)
Nausea (feeling of having an urge to vomit)
Neuropathy peripheral (surface nerve damage)
Shigella infection (bacterial infection caused by a family of bacteria known as shigella)
Urinary tract infection bacterial
Viral infection
Visual impairment
Vomiting

50-59:

Anaemia (lack of blood)
Angina unstable (chest pain due to ischemia of the heart muscle- unstable)
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Fatigue (feeling of tiredness)
Myalgia (muscle pain)
Syncope (loss of consciousness with an inability to maintain postural tone)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hysterectomy
Impaired gastric emptying

60+:

Hypotension (abnormally low blood pressure)
Fall
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Rehabilitation therapy
Haematemesis (vomiting of blood)
Haemorrhage (bleeding)
Limb injury
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)

What are the existing conditions these people have? *

Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 40 people, 43.48%
Parkinson's Disease: 17 people, 18.48%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 15 people, 16.30%
Fainting (loss of consciousness and postural tone): 10 people, 10.87%
Dizziness: 6 people, 6.52%
Hypotension (abnormally low blood pressure): 5 people, 5.43%
Back Pain: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

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