Northera and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Northera (droxidopa) and Provigil (modafinil). Common drug interactions include vomiting among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Northera and Provigil. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Northera?

Northera has active ingredients of droxidopa. eHealthMe is studying from 22,874 Northera users. Check the latest studies of Northera.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

On Aug, 02, 2026

25 people who take Northera and Provigil together, and have interactions are studied.

Northera and Provigil drug interactions.

What are the common drug interactions of Northera and Provigil, by gender? *:

female:

Vomiting
Dizziness
Blood pressure increased
Headache (pain in head)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Fall
Nausea (feeling of having an urge to vomit)
Loss of consciousness
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Gait disturbance

male:

Drug ineffective
Headache (pain in head)
Hepatitis c
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Postural orthostatic tachycardia syndrome (abnormal increase in heart rate on becoming upright)
Renal pain (kidney pain)
Type 2 diabetes mellitus
Chapped lips (cracking, fissuring, and peeling of the skin f lip)
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)

What are the common drug interactions of Northera and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal pain upper
Epistaxis (bleed from the nose)
Vomiting

30-39:

Fall
Loss of consciousness

40-49:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Vomiting
Blood potassium decreased
Gastrointestinal disorder (functional problems of gastrointestinal tract)

50-59:

Vomiting
Nausea (feeling of having an urge to vomit)
Abasia (inability to walk)
Asthenia (weakness)
Dizziness
Drug hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Hypotension (abnormally low blood pressure)
Dehydration (dryness resulting from the removal of water)
Hepatitis c

60+:

Headache (pain in head)
Dizziness
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Clavicle fracture
Death
Muscle rigidity (muscle stiffness)
Viral infection
Blood pressure increased
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 36.00%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 7 people, 28.00%
Parkinson's Disease: 5 people, 20.00%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 5 people, 20.00%
Hypotension (abnormally low blood pressure): 3 people, 12.00%
Pain: 2 people, 8.00%
Fatigue (feeling of tiredness): 2 people, 8.00%
Autonomic Failure Syndrome (a degenerative disease of the autonomic nervous system): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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