Nortriptyline hydrochloride and Epipen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nortriptyline hydrochloride (nortriptyline hydrochloride) and Epipen (epinephrine). Common drug interactions include therapeutic response unexpected among females and ear infection among males.

The phase IV clinical study analyzes what interactions people have when they take Nortriptyline hydrochloride and Epipen. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Nortriptyline hydrochloride?

Nortriptyline hydrochloride has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,817 Nortriptyline hydrochloride users. Check the latest studies of Nortriptyline hydrochloride.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.



On Aug, 09, 2026

26 people who take Nortriptyline hydrochloride and Epipen together, and have interactions are studied.

Nortriptyline hydrochloride and Epipen drug interactions.

What are the common drug interactions of Nortriptyline Hydrochloride and Epipen, by gender? *:

female:

  1. Therapeutic response unexpected
  2. Vomiting
  3. Affective disorder (mental disorder)
  4. Asthenia (weakness)
  5. Breast mass
  6. Diarrhoea
  7. Dizziness
  8. Drug dependence
  9. Emotional distress
  10. Fatigue (feeling of tiredness)

male:

  1. Ear infection
  2. Hypertension (high blood pressure)
  3. Immune system disorder
  4. Osteomyelitis (infection of bone)

What are the common drug interactions of Nortriptyline Hydrochloride and Epipen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Breast mass
  2. Diarrhoea
  3. Dizziness
  4. Hyperhidrosis (abnormally increased sweating)
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Sinusitis (inflammation of sinus)
  7. Immune system disorder

30-39:

  1. Hypertension (high blood pressure)

40-49:

  1. Angioedema (rapid swelling of the dermis)
  2. Hereditary angioedema (recurrent episodes of severe swelling)
  3. Pancreatitis (inflammation of pancreas)
  4. Transaminases increased
  5. Urinary tract infection
  6. Abdominal pain
  7. Biliary colic
  8. Drug intolerance (drug sensitivity)
  9. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
  10. Post procedural complication

50-59:

  1. Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
  2. Adrenal cyst (cysts of the adrenal gland)
  3. Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
  4. Drug hypersensitivity
  5. Ear infection
  6. Hospitalisation
  7. Kidney infection
  8. Osteomyelitis (infection of bone)
  9. Type 2 diabetes mellitus
  10. Weight decreased

60+:

  1. Arthralgia (joint pain)
  2. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  3. Fall
  4. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
  5. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  6. Limb injury
  7. Mass
  8. Nausea (feeling of having an urge to vomit)
  9. Oesophageal disorder (disease of oesophagus)
  10. Respiratory disorder (respiratory disease)

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 42.31%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 38.46%
  3. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 15.38%
  4. Pain: 4 people, 15.38%
  5. Asthma: 3 people, 11.54%
  6. Hypersensitivity: 3 people, 11.54%
  7. Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 3 people, 11.54%
  8. Bipolar Disorder (mood disorder): 2 people, 7.69%
  9. Drowsiness: 2 people, 7.69%
  10. Drug Hypersensitivity: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Nortriptyline hydrochloride and Epipen?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Nortriptyline hydrochloride and Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nortriptyline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nortriptyline hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epipen and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on nortriptyline hydrochloride and epinephrine (the active ingredients of Nortriptyline hydrochloride and Epipen, respectively), and Nortriptyline hydrochloride and Epipen (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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