Norvasc and Activase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norvasc (amlodipine besylate) and Activase (alteplase). Common drug interactions include pyrexia among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Norvasc and Activase. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Norvasc?

Norvasc has active ingredients of amlodipine besylate. It is often used in high blood pressure. eHealthMe is studying from 136,738 Norvasc users. Check the latest studies of Norvasc.

What is Activase?

Activase has active ingredients of alteplase. eHealthMe is studying from 7,526 Activase users. Check the latest studies of Activase.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

66 people who take Norvasc and Activase together, and have interactions are studied.

What are the common drug interactions of Norvasc and Activase, by gender? *:

female:

Pyrexia (fever)
Abscess (pus)
Back pain
Cough
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Gastritis (inflammation of stomach)
Insomnia (sleeplessness)
Nausea (feeling of having an urge to vomit)
Rash
Sinusitis (inflammation of sinus)

male:

Pyrexia (fever)
Oedema peripheral (superficial swelling)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Dyspnoea (difficult or laboured respiration)
Hallucination (an experience involving the perception of something not present)
Nausea (feeling of having an urge to vomit)
Tachypnoea (a condition of rapid breathing over 20 per minute)

What are the common drug interactions of Norvasc and Activase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Hypoxia (low oxygen in tissues)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pericardial effusion (fluid around the heart)
Pyrexia (fever)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Cough
Hyperglycaemia (high blood sugar)
Acute lymphocytic leukaemia (cancer of the white blood cells)
Agitation (state of anxiety or nervous excitement)

20-29:

n/a

30-39:

Abscess (pus)
Agitation (state of anxiety or nervous excitement)
Apathy
Apnoea (suspension of external breathing)
Arrhythmia (irregular heartbeat)
Back pain
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Blood pressure fluctuation
Cellulitis (infection under the skin)
Change of bowel habit

40-49:

Agitation (state of anxiety or nervous excitement)
Haemorrhage intracranial (bleeding within the skull)
Intracranial haematoma (intracranial localized swelling filled with blood)

50-59:

Cerebrovascular disorder (disease of brain)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Cyst (a closed sac)
Depression
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Empyema (collection of pus in a cavity in the body)
Eye discharge
Faecal incontinence (a lack of control over passing stool)
Fall

60+:

Febrile neutropenia (fever with reduced white blood cells)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood alkaline phosphatase increased
Blood urea increased
Bradycardia (abnormally slow heart action)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Dizziness
Encephalopathy (functioning of the brain is affected by some agent or condition)
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 9 people, 13.64%
Bone Density Abnormal: 8 people, 12.12%
Pain: 7 people, 10.61%
Febrile Neutropenia (fever with reduced white blood cells): 7 people, 10.61%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 6 people, 9.09%
Constipation: 6 people, 9.09%
Osteoporosis (bones weak and more likely to break): 5 people, 7.58%
Fever: 5 people, 7.58%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 5 people, 7.58%
Nausea (feeling of having an urge to vomit): 4 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Norvasc and Activase?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously