Novolog and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Novolog (insulin aspart recombinant) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include weight increased among females and blood glucose decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Novolog and Excedrin. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Novolog?

Novolog has active ingredients of insulin aspart recombinant. It is often used in diabetes. eHealthMe is studying from 56,160 Novolog users. Check the latest studies of Novolog.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 25, 2026

59 people who take Novolog and Excedrin together, and have interactions are studied.

What are the common drug interactions of Novolog and Excedrin, by gender? *:

female:

Weight increased
Wheezing (a high-pitched whistling sound made while you breath)
Abdominal pain upper
Acidosis (build-up of carbon dioxide in the blood)
Blood pressure increased
Blood urine present
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depressed mood
Diabetes mellitus inadequate control

male:

Blood glucose decreased
Blood glucose increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Chronic kidney disease
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)

What are the common drug interactions of Novolog and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nausea (feeling of having an urge to vomit)
Dizziness
Drug ineffective
Abdominal pain upper
Depressed mood
Fatigue (feeling of tiredness)
Hepatic enzyme increased
Hepatic pain (pain in liver)
Liver disorder (liver diseases)
Peripheral swelling

30-39:

Renal failure (kidney dysfunction)
Chronic kidney disease
Acute respiratory failure
Anxiety
Death
Depression
Diabetes mellitus inadequate control
Ketoacidosis (high concentrations of ketone bodies in blood)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal injury (kidney injury)

40-49:

Altered state of consciousness (altered state of mind)
Crepitations (noises are produced by the rubbing of parts one against the other)
Discomfort
Dyspnoea (difficult or laboured respiration)
Irritability
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Rales (an abnormal respiratory sound characterized by fine crackles)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary tract infection
Urinary tract infection pseudomonal

50-59:

Diarrhoea
Dizziness
Drug administration error
Drug ineffective
Extrasystoles
Eye discharge
Eye swelling
Eyelid cyst
Eyelid pain
Facial pain

60+:

Nasopharyngitis (inflammation of the nasopharynx)
Blood glucose increased
Depression
Dyspnoea (difficult or laboured respiration)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neoplasm progression (growth of tumour)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Rib fracture
Schizophrenia (a mental disorder characterized by a breakdown of thought processes)
Sleep disorder

What are the existing conditions these people have? *

Pain: 12 people, 20.34%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 20.34%
High Blood Cholesterol: 10 people, 16.95%
Type 2 Diabetes: 8 people, 13.56%
Migraine (headache): 7 people, 11.86%
Blood Glucose Increased: 7 people, 11.86%
Constipation: 7 people, 11.86%
High Blood Pressure: 7 people, 11.86%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 10.17%
Insomnia (sleeplessness): 4 people, 6.78%

* Approximation only. Some reports may have incomplete information.

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