Nplate and Duragesic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nplate (romiplostim) and Duragesic (fentanyl). Common drug interactions include deep vein thrombosis among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Nplate and Duragesic. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

What is Duragesic?

Duragesic has active ingredients of fentanyl. eHealthMe is studying from 66,597 Duragesic users. Check the latest studies of Duragesic.

On Jul, 28, 2026

22 people who take Nplate and Duragesic together, and have interactions are studied.

What are the common drug interactions of Nplate and Duragesic, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Thrombocytopenia (decrease of platelets in blood)
Asthenia (weakness)
Ascites (accumulation of fluid in the abdominal cavity)
Bone cyst
Bowel movement irregularity
Breast cancer metastatic
Cachexia (loss of weight)
Cough

male:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Headache (pain in head)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Thrombocytopenia (decrease of platelets in blood)
Abdominal hernia
Abdominal pain
Abnormal loss of weight
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the common drug interactions of Nplate and Duragesic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Overdose
Thrombocytopenia (decrease of platelets in blood)
Death

40-49:

Abdominal pain
Abdominal pain upper
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Drug ineffective
Dysuria (painful or difficult urination)
Epistaxis (bleed from the nose)
Eye irritation
Fatigue (feeling of tiredness)

50-59:

Fear
Gait disturbance
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastritis (inflammation of stomach)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
General physical health deterioration (weak health status)
Groin pain
Haematochezia (passage of stools containing blood)
Heart rate irregular
Hepatitis b

60+:

Pneumonia
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fall
Fatigue (feeling of tiredness)
Laceration (tearing of soft body tissue)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Splenomegaly (enlargement of spleen)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Hypovolaemic shock (shock caused by severe blood or fluid loss)

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 14 people, 63.64%
Pain: 4 people, 18.18%
Prostate Cancer: 3 people, 13.64%
Autoimmune Thrombocytopenia (isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Nplate and Duragesic?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously