Spiriva and Angle closure glaucoma - a phase IV clinical study of FDA data

Summary:

Angle closure glaucoma is reported as a side effect among people who take Spiriva (tiotropium bromide monohydrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Singulair, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Angle closure glaucoma when taking Spiriva. It is created by eHealthMe based on reports of 155,418 people who have side effects when taking Spiriva from the FDA, and is updated regularly.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

What is Angle closure glaucoma?

Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity) is found to be associated with 208 drugs and 480 conditions by eHealthMe. Check the latest studies of Angle closure glaucoma.

On Jul, 28, 2026

155,418 people reported to have side effects when taking Spiriva.
Among them, 47 people (0.03%) have Angle closure glaucoma.

Could Spiriva cause Angle closure glaucoma?

Among these 47 people:

How long have people been on Spiriva when they have Angle closure glaucoma? *

What is the gender of people who have Angle closure glaucoma when taking Spiriva? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Angle closure glaucoma when taking Spiriva? *

What are other drugs people take besides Spiriva? *

What are other side effects people have besides Angle closure glaucoma? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 16 people, 34.04%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 16 people, 34.04%
Fall: 16 people, 34.04%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 16 people, 34.04%
Joint Injury: 16 people, 34.04%
Bipolar Disorder (mood disorder): 16 people, 34.04%
Cataract (clouding of the lens inside the eye): 6 people, 12.77%
Eye Pain: 5 people, 10.64%
Accidental Exposure: 4 people, 8.51%
Visual Acuity Reduced (reduced clearness of vision): 4 people, 8.51%

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 6.38%
High Blood Pressure: 3 people, 6.38%
High Blood Cholesterol: 3 people, 6.38%
Ovarian Cancer (cancer of ovary): 2 people, 4.26%
Insomnia (sleeplessness): 2 people, 4.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 4.26%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 4.26%
Dyspnea (difficult or laboured breathing): 2 people, 4.26%
Bronchitis Chronic (inflammation of the mucous membrane in the bronchial tubes- chronic): 2 people, 4.26%
Back Pain: 2 people, 4.26%

* Approximation only. Some reports may have incomplete information.

Do you take Spiriva and have Angle closure glaucoma?

- Check whether Angle closure glaucoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spiriva:

Spiriva (156,666 reports)

Angle closure glaucoma treatments and more:

Angle closure glaucoma (3,261 reports)

How severe was Angle closure glaucoma and when was it recovered:

Angle closure glaucoma in Spiriva

Expand to all the drugs that have ingredients of tiotropium bromide monohydrate:

Angle closure glaucoma and drugs with ingredients of tiotropium bromide monohydrate (47 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Spiriva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angle closure glaucoma:

Angle closure glaucoma (208 drugs)

Browse all the conditions that are associated with Angle closure glaucoma:

Angle closure glaucoma (480 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tiotropium bromide monohydrate (the active ingredients of Spiriva) and Spiriva (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.