Nucynta and Benicar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Benicar (olmesartan medoxomil). Common drug interactions include hallucination among females and muscular weakness among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Benicar. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Benicar?

Benicar has active ingredients of olmesartan medoxomil. It is often used in high blood pressure. eHealthMe is studying from 36,002 Benicar users. Check the latest studies of Benicar.

On Jul, 14, 2026

41 people who take Nucynta and Benicar together, and have interactions are studied.

What are the common drug interactions of Nucynta and Benicar, by gender? *:

female:

Hallucination (an experience involving the perception of something not present)
Psychotic disorder
Somnolence (a state of near-sleep, a strong desire for sleep)
Discomfort
Drug hypersensitivity
Fatigue (feeling of tiredness)
Adnexa uteri pain
Bacteriuria (presence of bacteria in urine)
Balance disorder
Blood urea increased

male:

Muscular weakness (muscle weakness)
Chest pain
Diarrhoea
Suicidal ideation
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nephrogenic anaemia (anaemia due to kidney disease)
Appetite disorder (abnormal eating habits)
Blindness
Cardiac murmur (an heart sound in valve abnormality)
Cataract (clouding of the lens inside the eye)

What are the common drug interactions of Nucynta and Benicar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injection site urticaria (rash of round, red welts on the skin at injection site)
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Surgical failure

40-49:

Depression
Suicidal ideation
Adnexa uteri pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Diarrhoea
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Malaise (a feeling of general discomfort or uneasiness)
Ovarian cyst (fluid filled sac of the ovary)
Ovarian cyst ruptured (tear in fluid filled sac of the ovary)

50-59:

Drug hypersensitivity
Discomfort
Dysphonia (speech disorder attributable to a disorder of phonation)
Hepatic enzyme increased
Oropharyngeal pain
Somnolence (a state of near-sleep, a strong desire for sleep)

60+:

Muscular weakness (muscle weakness)
Chest pain
Somnolence (a state of near-sleep, a strong desire for sleep)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Renal failure (kidney dysfunction)
Appetite disorder (abnormal eating habits)
Blindness
Cardiac murmur (an heart sound in valve abnormality)
Cataract (clouding of the lens inside the eye)
Contusion (a type of hematoma of tissue in which capillaries)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 26.83%
Chest Pain: 7 people, 17.07%
Prostate Cancer: 6 people, 14.63%
Asthma: 5 people, 12.20%
Procedural Pain: 4 people, 9.76%
Neuralgia (pain in one or more nerves): 4 people, 9.76%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 9.76%
High Blood Cholesterol: 4 people, 9.76%
Diabetes: 4 people, 9.76%
Depression: 4 people, 9.76%

* Approximation only. Some reports may have incomplete information.

Do you take Nucynta and Benicar?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously