Nuedexta and Hctz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nuedexta (dextromethorphan hydrobromide; quinidine sulfate) and Hctz (hydrochlorothiazide). Common drug interactions include depression among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Nuedexta and Hctz. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Nuedexta?

Nuedexta has active ingredients of dextromethorphan hydrobromide; quinidine sulfate. eHealthMe is studying from 3,781 Nuedexta users. Check the latest studies of Nuedexta.

What is Hctz?

Hctz has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 24,823 Hctz users. Check the latest studies of Hctz.

On Jul, 15, 2026

20 people who take Nuedexta and Hctz together, and have interactions are studied.

What are the common drug interactions of Nuedexta and Hctz, by gender? *:

female:

Depression
Malaise (a feeling of general discomfort or uneasiness)
Pain
Peripheral swelling
Arthralgia (joint pain)
Asthenia (weakness)
Burning sensation
Constipation
Fatigue (feeling of tiredness)
Influenza

male:

Fall
Asthenia (weakness)
Drug ineffective
Hallucination (an experience involving the perception of something not present)
Stress
Therapeutic response unexpected
Fatigue (feeling of tiredness)
Mobility decreased (ability to move is reduced)
Visual impairment
Death

What are the common drug interactions of Nuedexta and Hctz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Asthenia (weakness)
Burning sensation
Constipation
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pain in extremity
Peripheral swelling

60+:

Agitation (state of anxiety or nervous excitement)
Abnormal behaviour
Depression
Fall
Gait disturbance
Insomnia (sleeplessness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal discomfort
Asthenia (weakness)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the existing conditions these people have? *

Stress And Anxiety: 5 people, 25.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 25.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 20.00%
High Blood Cholesterol: 3 people, 15.00%
Type 2 Diabetes: 3 people, 15.00%
Tardive Dyskinesia (a disorder that involves involuntary movements): 3 people, 15.00%
Crying: 3 people, 15.00%
Pain: 3 people, 15.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 15.00%
Agitation (state of anxiety or nervous excitement): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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