Nuedexta and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nuedexta (dextromethorphan hydrobromide; quinidine sulfate) and Modafinil (modafinil). Common drug interactions include multiple sclerosis relapse among females and deep vein thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Nuedexta and Modafinil. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Nuedexta?

Nuedexta has active ingredients of dextromethorphan hydrobromide; quinidine sulfate. eHealthMe is studying from 3,781 Nuedexta users. Check the latest studies of Nuedexta.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 11, 2026

65 people who take Nuedexta and Modafinil together, and have interactions are studied.

Nuedexta and Modafinil drug interactions.

What are the common drug interactions of Nuedexta and Modafinil, by gender? *:

female:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Depression
Fatigue (feeling of tiredness)
Balance disorder
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Pain in extremity
Fall
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Mobility decreased (ability to move is reduced)
Pain

male:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Fall
Flushing (the warm, red condition of human skin)
Loss of consciousness
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Tremor (trembling or shaking movements in one or more parts of your body)
Road traffic accident
Tibia fracture (fracture of lower leg bone)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the common drug interactions of Nuedexta and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Restless legs syndrome (a powerful urge to move your legs)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Skin disorder (skin disease)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)
Road traffic accident
Tibia fracture (fracture of lower leg bone)
Electrocardiogram qt prolonged

40-49:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Depression
Balance disorder
Pain in extremity
Fall
Fatigue (feeling of tiredness)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Mobility decreased (ability to move is reduced)
Pain
Accident

50-59:

Fatigue (feeling of tiredness)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Eye disorder
Facial paralysis (loss of function of face muscle)
Incontinence (lack of moderation or self-control)
Insomnia (sleeplessness)
Leukocytosis (increased white blood cells)
Memory impairment
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)

60+:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 54 people, 83.08%
Gait Disturbance: 23 people, 35.38%
Affect Lability (emotional incontinence): 8 people, 12.31%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 7 people, 10.77%
Fatigue (feeling of tiredness): 7 people, 10.77%
Depression: 7 people, 10.77%
Pain: 4 people, 6.15%
Neuralgia (pain in one or more nerves): 4 people, 6.15%
Immunodeficiency Common Variable: 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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