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Nuvigil and Parnate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nuvigil (armodafinil) and Parnate (tranylcypromine sulfate). Common drug interactions include irritable bowel syndrome among females and insomnia among males.

The phase IV clinical study analyzes what interactions people have when they take Nuvigil and Parnate. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Nuvigil?

Nuvigil has active ingredients of armodafinil. It is often used in narcolepsy. eHealthMe is studying from 23,669 Nuvigil users. Check the latest studies of Nuvigil.

What is Parnate?

Parnate has active ingredients of tranylcypromine sulfate. It is often used in depression. eHealthMe is studying from 1,131 Parnate users. Check the latest studies of Parnate.

On Jul, 14, 2026

11 people who take Nuvigil and Parnate together, and have interactions are studied.

Nuvigil and Parnate drug interactions.

What are the common drug interactions of Nuvigil and Parnate, by gender? *:

female:

  1. Irritable bowel syndrome
  2. Osteopenia (a condition where bone mineral density is lower than normal)
  3. Rosacea (a skin condition that causes facial redness)
  4. Bipolar disorder (mood disorder)
  5. Bulimia nervosa (eating disorder characterized by recurrent binge eating, followed by compensatory behaviours)
  6. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  7. Gastrointestinal injury (injury to gastrointestinal tract)
  8. Intestinal obstruction
  9. Victim of abuse
  10. Volvulus (obstruction caused by twisting of the stomach or intestine)

male:

  1. Insomnia (sleeplessness)
  2. Salivary hypersecretion (excess saliva secretion)

What are the common drug interactions of Nuvigil and Parnate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Peripheral swelling
  2. Weight increased

50-59:

n/a

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Suicidal ideation
  3. Vomiting
  4. Insomnia (sleeplessness)
  5. Salivary hypersecretion (excess saliva secretion)

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 27.27%
  2. Stress And Anxiety: 2 people, 18.18%
  3. Hypersensitivity: 2 people, 18.18%
  4. Indigestion: 1 person, 9.09%
  5. Fatigue (feeling of tiredness): 1 person, 9.09%
  6. Drowsiness: 1 person, 9.09%
  7. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 9.09%
  8. Back Pain: 1 person, 9.09%
  9. Asthma: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Nuvigil and Parnate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Nuvigil and Parnate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nuvigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Parnate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nuvigil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Parnate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on armodafinil and tranylcypromine sulfate (the active ingredients of Nuvigil and Parnate, respectively), and Nuvigil and Parnate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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