Nyquil and Ampyra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine) and Ampyra (dalfampridine). Common drug interactions include headache among females and hypokinesia among males.

The phase IV clinical study analyzes what interactions people have when they take Nyquil and Ampyra. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

What is Ampyra?

Ampyra has active ingredients of dalfampridine. It is often used in multiple sclerosis. eHealthMe is studying from 77,145 Ampyra users. Check the latest studies of Ampyra.

On Jul, 21, 2026

11 people who take Nyquil and Ampyra together, and have interactions are studied.

What are the common drug interactions of Nyquil and Ampyra, by gender? *:

female:

Headache (pain in head)
Dizziness
Abasia (inability to walk)
Depression
Drug ineffective
Gait disturbance
Influenza
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Hypokinesia (decreased bodily movement)
Memory impairment
Pain in extremity
Gait disturbance
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Therapeutic response unexpected
Back pain
Constipation
Drug ineffective

What are the common drug interactions of Nyquil and Ampyra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hypokinesia (decreased bodily movement)
Memory impairment
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Therapeutic response unexpected
Gait disturbance
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

40-49:

Abasia (inability to walk)
Depression
Drug ineffective
Gait disturbance
Influenza
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Secretion discharge

50-59:

Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Pain in extremity
Feeling hot
Headache (pain in head)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Back pain
Constipation
Drug ineffective
Mobility decreased (ability to move is reduced)

60+:

Dizziness
Headache (pain in head)
Hypersensitivity
Pruritus (severe itching of the skin)
Rash

What are the existing conditions these people have? *

Gait Disturbance: 6 people, 54.55%
Pain: 2 people, 18.18%
Headache (pain in head): 2 people, 18.18%
Back Pain: 2 people, 18.18%
Sleep Disorder: 1 person, 9.09%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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