Nyquil and Vitamin e drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine) and Vitamin e (tocopherols and tocotrienols). Common drug interactions include malaise among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Nyquil and Vitamin e. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

On Jul, 23, 2026

23 people who take Nyquil and Vitamin e together, and have interactions are studied.

What are the common drug interactions of Nyquil and Vitamin E, by gender? *:

female:

Malaise (a feeling of general discomfort or uneasiness)
Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood pressure increased
Death
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Diarrhoea

male:

Blood cholesterol increased
Nasopharyngitis (inflammation of the nasopharynx)
Enuresis (repeated inability to control urination)
Heart rate irregular
Influenza
Injection site rash
Mood altered (changes in mood)
Nausea (feeling of having an urge to vomit)
Ocular icterus (presence of jaundice seen in the sclera of the eye)
Pain

What are the common drug interactions of Nyquil and Vitamin E, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased

30-39:

Fungal infection
Gestational diabetes (diabetes in pregnancy)
Influenza
Maternal exposure before pregnancy (use of substance before pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)
Nasopharyngitis (inflammation of the nasopharynx)
Nightmare (unpleasant dream)
Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Stress

40-49:

Localised infection (infection at the single location)
Osteomyelitis (infection of bone)
Skin ulcer

50-59:

Acidosis (build-up of carbon dioxide in the blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chronic kidney disease
Death
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Dyspnoea exertional (breathlessness or shortness of breath)
Heart rate irregular
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

60+:

Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Glossodynia (a burning or painful sensation in the tongue)
Hair colour changes
Hyperkeratosis (thickening of the outer layer of the skin)
Hypotension (abnormally low blood pressure)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Influenza
Injection site rash
Joint swelling

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 43.48%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 26.09%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.70%
High Blood Pressure: 2 people, 8.70%
Drowsiness: 2 people, 8.70%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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