Ofev and Nitrostat drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ofev (nintedanib esylate) and Nitrostat (nitroglycerin). Common drug interactions include aspartate aminotransferase increased among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Ofev and Nitrostat. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Ofev?

Ofev has active ingredients of nintedanib esylate. eHealthMe is studying from 24,791 Ofev users. Check the latest studies of Ofev.

What is Nitrostat?

Nitrostat has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 14,082 Nitrostat users. Check the latest studies of Nitrostat.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

44 people who take Ofev and Nitrostat together, and have interactions are studied.

What are the common drug interactions of Ofev and Nitrostat, by gender? *:

female:

Aspartate aminotransferase increased
Blood urine present
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Contusion (a type of hematoma of tissue in which capillaries)
Depressed mood
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspepsia (indigestion)
Fall
Flatulence (flatus expelled through the anus)
Gallbladder disorder

male:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Productive cough
Oxygen saturation decreased
Blood glucose increased
Blood pressure fluctuation
Gait disturbance
Haematochezia (passage of stools containing blood)
Hepatic enzyme increased

What are the common drug interactions of Ofev and Nitrostat, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Lung neoplasm malignant (cancer tumour of lung)
Productive cough
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Urinary tract infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Coagulopathy (blood's ability to clot is impaired)
Diarrhoea
Tremor (trembling or shaking movements in one or more parts of your body)
Nausea (feeling of having an urge to vomit)

60+:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Dizziness
Fatigue (feeling of tiredness)
Decreased appetite
Hypotension (abnormally low blood pressure)
Productive cough
Abdominal pain
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)

What are the existing conditions these people have? *

Idiopathic Pulmonary Fibrosis (chronic lung disease): 38 people, 86.36%
Interstitial Lung Disease: 9 people, 20.45%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 6.82%
High Blood Pressure: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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