Olysio and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Olysio (simeprevir) and Zantac (ranitidine hydrochloride). Common drug interactions include general physical health deterioration among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Olysio and Zantac. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Olysio?

Olysio has active ingredients of simeprevir. eHealthMe is studying from 3,076 Olysio users. Check the latest studies of Olysio.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

25 people who take Olysio and Zantac together, and have interactions are studied.

What are the common drug interactions of Olysio and Zantac, by gender? *:

female:

General physical health deterioration (weak health status)
Renal impairment (severely reduced kidney function)
Hospitalisation
Cardiac failure
Dyspnoea (difficult or laboured respiration)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Lung adenocarcinoma (a form of non-small cell lung cancer)
Procedural pain
Pyelonephritis (inflammation of kidney caused by bacteria)
Vulvovaginal mycotic infection (vulvovaginal fungal infection)

male:

Asthenia (weakness)
Blood alkaline phosphatase increased
Somnolence (a state of near-sleep, a strong desire for sleep)
Depression
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Increased appetite
Insomnia (sleeplessness)
Irritability
Photosensitivity reaction
Sunburn

What are the common drug interactions of Olysio and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Depression
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Increased appetite
Insomnia (sleeplessness)
Irritability
Photosensitivity reaction
Sunburn

50-59:

Vulvovaginal mycotic infection (vulvovaginal fungal infection)
Death
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Lung adenocarcinoma (a form of non-small cell lung cancer)
Procedural pain
Pyelonephritis (inflammation of kidney caused by bacteria)

60+:

General physical health deterioration (weak health status)
Renal impairment (severely reduced kidney function)
Hospitalisation
Cardiac failure
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Hepatitis C: 22 people, 88.00%
Hepatocellular Carcinoma (liver cancer): 18 people, 72.00%
High Blood Pressure: 3 people, 12.00%
Diabetes: 2 people, 8.00%
Cough: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Olysio and Zantac?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously