Omega-3 and Oxycontin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Omega-3 (cod liver oil) and Oxycontin (oxycodone hydrochloride). Common drug interactions include anhedonia among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Omega-3 and Oxycontin. It is created by eHealthMe based on reports of 97 people who take the same drugs from the FDA, and is updated regularly.

What is Omega-3?

Omega-3 has active ingredients of cod liver oil. It is often used in high blood cholesterol. eHealthMe is studying from 3,482 Omega-3 users. Check the latest studies of Omega-3.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

97 people who take Omega-3 and Oxycontin together, and have interactions are studied.

Omega-3 and Oxycontin drug interactions.

What are the common drug interactions of Omega-3 and Oxycontin, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Body height decreased
Death
Dysstasia (difficulty in standing)
Emotional distress
Malignant neoplasm progression (cancer tumour came back)
Memory impairment
Multiple fractures
Nasopharyngitis (inflammation of the nasopharynx)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Fatigue (feeling of tiredness)
Cardiac failure congestive
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Dehydration (dryness resulting from the removal of water)
Dysgeusia (disorder of the sense of taste)
Fluid intake reduced
Gastrointestinal stromal tumour (a cancer that arises from transformed cells of mesenchymal origin in gastrointestinal tract)
Haemoglobin decreased
Headache (pain in head)

What are the common drug interactions of Omega-3 and Oxycontin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Dehydration (dryness resulting from the removal of water)
Blood pressure systolic increased
Grip strength decreased
Heart rate decreased
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Oxygen saturation decreased
Peripheral swelling
Sleep disorder

60+:

Fatigue (feeling of tiredness)
Renal impairment (severely reduced kidney function)
Presbyacusis (age-related hearing loss)
Drug ineffective
Pleural fibrosis (formation of fibrous tissue in lung)
Blood creatinine increased
Drug intolerance (drug sensitivity)
Epigastric discomfort
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infection

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 74 people, 76.29%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 56 people, 57.73%
Sleep Disorder: 47 people, 48.45%
Dry Eyes (lack of adequate tears): 39 people, 40.21%
Adenomatous Polyposis Coli ((fap) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine): 22 people, 22.68%
Immunodeficiency Common Variable: 7 people, 7.22%
Restless Leg Syndrome (a powerful urge to move your legs): 6 people, 6.19%

* Approximation only. Some reports may have incomplete information.

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