Omeprazole and Differin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Omeprazole (omeprazole) and Differin (adapalene). Common drug interactions include anxiety among females and foot fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Omeprazole and Differin. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,631 Omeprazole users. Check the latest studies of Omeprazole.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

37 people who take Omeprazole and Differin together, and have interactions are studied.

Omeprazole and Differin drug interactions.

What are the common drug interactions of Omeprazole and Differin, by gender? *:

female:

Anxiety
Erythema (redness of the skin)
Pain
Renal failure (kidney dysfunction)
Chronic kidney disease
Dry skin
Nephrogenic anaemia (anaemia due to kidney disease)
Palpitations (feelings or sensations that your heart is pounding or racing)
Bone density decreased
Bone marrow failure

male:

Foot fracture
Joint range of motion decreased (disease of joint movement)
Mass
Pain in extremity
Postoperative wound complication
Purulence (containing pus)
Scar
Tendon injury
Wound complication
Wound infection staphylococcal

What are the common drug interactions of Omeprazole and Differin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Diarrhoea
Feeding disorder (when children refuse to eat certain food groups)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hospitalisation
Intestinal obstruction
Nausea (feeling of having an urge to vomit)
Pneumonia
Vomiting
Vulvovaginal mycotic infection (vulvovaginal fungal infection)

20-29:

Bone marrow failure
Normochromic normocytic anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)
Scotoma (an area of diminished vision within the visual field)
Thyroid neoplasm (tumour of thyroid)
Vasculitis (inflammation of a blood vessel or blood vessels)

30-39:

Anxiety
Asthma
Emotional distress
Facet joint syndrome (problem with movement of the facet joints of the spine)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
General physical health deterioration (weak health status)
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Pain

40-49:

Dry skin
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Hallucination, olfactory (sensations of smelling something that is actually not there)
Hallucination, visual (seeing things that aren't there)
Headache (pain in head)
Injection site pain
Memory impairment
Nausea (feeling of having an urge to vomit)

50-59:

Abscess limb (limb infection)
Erythema (redness of the skin)
Groin abscess (pus in groin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Urinary tract infection
Anal abscess
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased

60+:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Palpitations (feelings or sensations that your heart is pounding or racing)
Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Ventricular extrasystoles (premature cardiac contraction)
Death
Renal failure (kidney dysfunction)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dry skin

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 24.32%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 13.51%
Insomnia (sleeplessness): 4 people, 10.81%
Depression: 4 people, 10.81%
Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 10.81%
Hypersensitivity: 3 people, 8.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 8.11%
Cystic Fibrosis (disease of the secretary glands): 3 people, 8.11%
Irritable Bowel Syndrome: 3 people, 8.11%
Asthma: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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