Omeprazole and Symtuza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Omeprazole (omeprazole) and Symtuza (darunavir;cobicistat;emtricitabine;tenofovir alafenamide). Common drug interactions include lower limb fracture among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Omeprazole and Symtuza. It is created by eHealthMe based on reports of 63 people who take the same drugs from the FDA, and is updated regularly.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,631 Omeprazole users. Check the latest studies of Omeprazole.

What is Symtuza?

Symtuza has active ingredients of darunavir;cobicistat;emtricitabine;tenofovir alafenamide. It is often used in hiv infection. eHealthMe is studying from 3,149 Symtuza users. Check the latest studies of Symtuza.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

63 people who take Omeprazole and Symtuza together, and have interactions are studied.

Omeprazole and Symtuza drug interactions.

What are the common drug interactions of Omeprazole and Symtuza, by gender? *:

female:

Lower limb fracture
Multiple fractures
Pancreatic disorder
Quality of life decreased
Renal failure (kidney dysfunction)
Suicidal ideation
Tibia fracture (fracture of lower leg bone)
Abdominal pain
Anaemia (lack of blood)
Arthropathy

male:

Emotional distress
Pain
Multiple fractures
Osteonecrosis (death of bone)
Tooth loss
Fatigue (feeling of tiredness)
Arthralgia (joint pain)
Bone loss
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Hypertension (high blood pressure)

What are the common drug interactions of Omeprazole and Symtuza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Chronic kidney disease
Fatigue (feeling of tiredness)
Quality of life decreased
Renal failure (kidney dysfunction)
Arthralgia (joint pain)

40-49:

Depression
Dysstasia (difficulty in standing)
Fall
Hip fracture
Lower limb fracture
Mobility decreased (ability to move is reduced)
Multiple fractures
Osteonecrosis (death of bone)
Renal impairment (severely reduced kidney function)
Rib fracture

50-59:

Emotional distress
Pain
Anxiety
Bone density decreased
Osteopenia (a condition where bone mineral density is lower than normal)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Depression
Renal failure (kidney dysfunction)
Tooth loss

60+:

Anxiety
Emotional distress
Back pain
Chronic kidney disease
Clavicle fracture
Depression
Dizziness
Gait disturbance
Impaired healing
Injection site erythema (redness at injection site)

What are the existing conditions these people have? *

Pain: 10 people, 15.87%
Inflammation: 6 people, 9.52%
Asthma: 6 people, 9.52%
Hypersensitivity: 5 people, 7.94%
Bacterial Infection: 5 people, 7.94%
Stress And Anxiety: 4 people, 6.35%
Nausea (feeling of having an urge to vomit): 4 people, 6.35%
High Blood Pressure: 4 people, 6.35%
Diabetes: 4 people, 6.35%
Depression: 4 people, 6.35%

* Approximation only. Some reports may have incomplete information.

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