Opana er and Omeprazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opana er (oxymorphone hydrochloride) and Omeprazole (omeprazole). Common drug interactions include sciatica among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Opana er and Omeprazole. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Opana er?

Opana er has active ingredients of oxymorphone hydrochloride. It is often used in pain. eHealthMe is studying from 33,986 Opana er users. Check the latest studies of Opana er.

What is Omeprazole?

Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 410,631 Omeprazole users. Check the latest studies of Omeprazole.

On Jul, 13, 2026

51 people who take Opana er and Omeprazole together, and have interactions are studied.

Opana er and Omeprazole drug interactions.

What are the common drug interactions of Opana Er and Omeprazole, by gender? *:

female:

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Skin exfoliation (removal of the oldest dead skin cells)
Skin haemorrhage (bleeding into skin)
Skin mass
Swelling
Balance disorder
Cough
Fall
Limb injury
Neutropenia (an abnormally low number of neutrophils)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Acute abdomen
Angina pectoris (chest pain due to ischemia of the heart muscle)
Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)

What are the common drug interactions of Opana Er and Omeprazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

C-reactive protein increased
Chills (felling of cold)
Chronic kidney disease
Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)
Colitis ulcerative (inflammation of colon with ulcer)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug intolerance (drug sensitivity)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Traumatic fracture (a fracture due to sustained trauma)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Blood cholesterol increased
Depression
Diarrhoea

60+:

Chronic kidney disease
Cough
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vomiting
Fatigue (feeling of tiredness)
Neutropenia (an abnormally low number of neutrophils)
Weight decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 27.45%
Depression: 14 people, 27.45%
High Blood Cholesterol: 13 people, 25.49%
Infection: 12 people, 23.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 17.65%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 15.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 15.69%
Asthma: 6 people, 11.76%
Diabetes: 6 people, 11.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 9.80%

* Approximation only. Some reports may have incomplete information.

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