Opsumit and Abilify drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Abilify (aripiprazole). Common drug interactions include musculoskeletal stiffness among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Abilify. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Abilify?

Abilify has active ingredients of aripiprazole. It is often used in depression. eHealthMe is studying from 101,455 Abilify users. Check the latest studies of Abilify.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

72 people who take Opsumit and Abilify together, and have interactions are studied.

What are the common drug interactions of Opsumit and Abilify, by gender? *:

female:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Peripheral swelling
Platelet count decreased
Prerenal failure
Pulmonary oedema (fluid accumulation in the lungs)
Rectal haemorrhage (bleeding from anus)
Respiratory failure (inadequate gas exchange by the respiratory system)
Sinusitis (inflammation of sinus)

male:

Abdominal discomfort
Anxiety
Migraine (headache)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nausea (feeling of having an urge to vomit)
Nervousness
Pneumonia
Poor quality sleep
Pulmonary hypertension (increase in blood pressure in the lung artery)
Rash

What are the common drug interactions of Opsumit and Abilify, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Chest pain
Crying
Syncope (loss of consciousness with an inability to maintain postural tone)
Abdominal pain
Blood potassium decreased
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Nausea (feeling of having an urge to vomit)
Vomiting

30-39:

Psychotic disorder
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Nausea (feeling of having an urge to vomit)
Diarrhoea
Haematemesis (vomiting of blood)
Hospitalisation
Pain
Platelet count decreased
Prerenal failure
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

40-49:

Dry mouth
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Pulmonary oedema (fluid accumulation in the lungs)
Weight increased
Disease progression
Pulmonary hypertension (increase in blood pressure in the lung artery)
Haematochezia (passage of stools containing blood)

50-59:

Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Urine output decreased
Vertigo
Viral upper respiratory tract infection
Abdominal discomfort
Myalgia (muscle pain)
Sputum discoloured
Cardiac failure congestive
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)

60+:

Dyspnoea (difficult or laboured respiration)
Chest pain
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cough
International normalised ratio increased
Pneumonia
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Acute respiratory failure
Cardiac disorder
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 62 people, 86.11%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 7 people, 9.72%
Psychotic Disorder: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Opsumit and Abilify?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously