Opsumit and Cefazolin sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Cefazolin sodium (cefazolin sodium). Common drug interactions include erythema among females and hypoxia among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Cefazolin sodium. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Cefazolin sodium?

Cefazolin sodium has active ingredients of cefazolin sodium. eHealthMe is studying from 3,649 Cefazolin sodium users. Check the latest studies of Cefazolin sodium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

50 people who take Opsumit and Cefazolin sodium together, and have interactions are studied.

Opsumit and Cefazolin sodium drug interactions.

What are the common drug interactions of Opsumit and Cefazolin Sodium, by gender? *:

female:

Erythema (redness of the skin)
Pco2 decreased
Po2 decreased
Pruritus (severe itching of the skin)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Vasculitis (inflammation of a blood vessel or blood vessels)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Abdominal distension

male:

Hypoxia (low oxygen in tissues)
Anaemia (lack of blood)
Granulocyte count decreased
Haematochezia (passage of stools containing blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Pneumonia
Post procedural haemorrhage (post procedural bleeding)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Rash
Right ventricular failure (right half of the heart fails to work)

What are the common drug interactions of Opsumit and Cefazolin Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Hypoxia (low oxygen in tissues)

10-19:

n/a

20-29:

Platelet count decreased
Extrasystoles
Atelectasis (partial or complete collapse of the lung)
Anaemia (lack of blood)
White blood cell count decreased
Diarrhoea
Epistaxis (bleed from the nose)
Headache (pain in head)
Brain natriuretic peptide increased
Pulmonary alveolar haemorrhage (acute bleeding)

30-39:

Anaemia (lack of blood)
Device related infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardioversion
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Biliary colic
Catheter site infection (infection at the site of insertion)
Cholecystitis acute (rapid infection of gallbladder)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Epistaxis (bleed from the nose)

40-49:

Abdominal pain
Atypical mycobacterial infection (infections caused by several types of mycobacterium similar to the germ that causes tuberculosis)
Device related infection
Drug eruption (adverse drug reaction of the skin)
Nausea (feeling of having an urge to vomit)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urticaria (rash of round, red welts on the skin that itch intensely)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Palpitations (feelings or sensations that your heart is pounding or racing)

50-59:

Nausea (feeling of having an urge to vomit)
Pco2 decreased
Po2 decreased
Pruritus (severe itching of the skin)
Pseudomembranous colitis (antibiotic-associated diarrhoea (aad), is an infection of the colon)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vomiting
Erythema (redness of the skin)
Arthralgia (joint pain)

60+:

Renal impairment (severely reduced kidney function)
Anaemia (lack of blood)
Blood pressure decreased
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Device related infection
Fall
Headache (pain in head)
Hot flush (sudden feelings of heat)
Hypokalaemia (low potassium)
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 47 people, 94.00%
Hypokalemia (low potassium): 16 people, 32.00%
Sedation: 12 people, 24.00%
Right Ventricular Failure (right half of the heart fails to work): 12 people, 24.00%
Cardiac Failure: 11 people, 22.00%
Fever: 11 people, 22.00%
Device Related Infection: 10 people, 20.00%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 9 people, 18.00%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 8 people, 16.00%
Infection: 7 people, 14.00%

* Approximation only. Some reports may have incomplete information.

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