Opsumit and Celecoxib drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Celecoxib (celecoxib). Common drug interactions include arthritis bacterial among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Celecoxib. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Celecoxib?

Celecoxib has active ingredients of celecoxib. It is often used in arthritis. eHealthMe is studying from 38,217 Celecoxib users. Check the latest studies of Celecoxib.

On Aug, 09, 2026

56 people who take Opsumit and Celecoxib together, and have interactions are studied.

Opsumit and Celecoxib drug interactions.

What are the common drug interactions of Opsumit and Celecoxib, by gender? *:

female:

Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Blood triglycerides increased
Clubbing (deformity of the fingers and fingernails)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Escherichia infection (bacterial infection by escherichia coli)
Flat affect (absence of emotional response to a situation)
Haematocrit decreased
Haemoglobin decreased

male:

Cough
Malaise (a feeling of general discomfort or uneasiness)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Pyrexia (fever)
White blood cell count increased
Arthralgia (joint pain)
Iron deficiency
Lung neoplasm malignant (cancer tumour of lung)
Oxygen consumption decreased
Pneumonia

What are the common drug interactions of Opsumit and Celecoxib, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Blood pressure decreased
Blood triglycerides increased
Dyspepsia (indigestion)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Insomnia (sleeplessness)
Narcolepsy (brain's inability to regulate sleep-wake cycles normally)
Nausea (feeling of having an urge to vomit)

20-29:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Gastroenteritis (inflammation of stomach and intestine)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Ligament sprain (ligament stretched)
Nasopharyngitis (inflammation of the nasopharynx)
Oedema peripheral (superficial swelling)
Palpitations (feelings or sensations that your heart is pounding or racing)
Peripheral swelling
Rhinitis allergic (inflammation of the nasal airways due to allergy)

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Gamma-glutamyltransferase increased
Heart rate increased
Malaise (a feeling of general discomfort or uneasiness)
Oxygen saturation decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)
Respiratory rate decreased (less breathing rate/min)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

40-49:

Arthralgia (joint pain)
Diarrhoea
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Pulmonary alveolar haemorrhage (acute bleeding)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hyperthyroidism (over activity of the thyroid gland)
Arrhythmia (irregular heartbeat)
Chest pain
Cough

50-59:

Pneumonia
Productive cough
Pyrexia (fever)
Right ventricular hypertrophy (right ventricular enlargement)
Arthritis bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)
Epistaxis (bleed from the nose)
Hot flush (sudden feelings of heat)
Interstitial lung disease
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)
Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas)

60+:

Headache (pain in head)
Diarrhoea
Abdominal pain
Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Aggression
Back pain
Bacteraemia (presence of bacteria in the blood)
Cardiac failure
Cystitis (inflammation of the wall of the bladder)
Drug dependence

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 50 people, 89.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 21.43%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 8 people, 14.29%
Cardiac Failure: 8 people, 14.29%
Joint Pain: 7 people, 12.50%
Constipation: 6 people, 10.71%
Asthma: 6 people, 10.71%
Thyroid Diseases: 5 people, 8.93%
Osteoporosis (bones weak and more likely to break): 5 people, 8.93%
Insomnia (sleeplessness): 5 people, 8.93%

* Approximation only. Some reports may have incomplete information.

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