Opsumit and Jardiance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Jardiance (empagliflozin). Common drug interactions include pain in jaw among females and cough among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Jardiance. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Jardiance?

Jardiance has active ingredients of empagliflozin. It is often used in hyperglycemia. eHealthMe is studying from 44,457 Jardiance users. Check the latest studies of Jardiance.

On Jul, 15, 2026

91 people who take Opsumit and Jardiance together, and have interactions are studied.

Opsumit and Jardiance drug interactions.

What are the common drug interactions of Opsumit and Jardiance, by gender? *:

female:

Pain in jaw
Oxygen saturation decreased
Abdominal distension
Abnormal loss of weight
Cardiac failure congestive
Dyspepsia (indigestion)
Flushing (the warm, red condition of human skin)
Lip swelling
Peripheral swelling
Vomiting

male:

Cough
Pyrexia (fever)
Hypervolaemia (abnormally increased volume of blood)
Hypokalaemia (low potassium)
Acute right ventricular failure (acute heart attack)
Respiratory tract infection
Sudden death
Vomiting
Adverse event
Asthenia (weakness)

What are the common drug interactions of Opsumit and Jardiance, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Nasopharyngitis (inflammation of the nasopharynx)
Abdominal distension
Acute sinusitis
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Bronchitis viral (inflammation of the mucous membrane in the bronchial tubes due to infection with streptococcus pneumoniae)
Cardiac failure acute
Cellulitis (infection under the skin)

50-59:

Pneumonia
Weight decreased
Abdominal pain upper
Bone pain
Cardiac failure congestive
Device occlusion
Feeling hot
Flushing (the warm, red condition of human skin)
Memory impairment
Myalgia (muscle pain)

60+:

Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Respiratory tract haemorrhage (respiratory tract bleeding)
Hypokalaemia (low potassium)
Abdominal distension
Acute right ventricular failure (acute heart attack)
Fall
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
General physical health deterioration (weak health status)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 77 people, 84.62%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 8 people, 8.79%
Type 2 Diabetes: 7 people, 7.69%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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