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Clozaril and Left ventricular failure - a phase IV clinical study of FDA data

Summary:

Left ventricular failure is reported as a side effect among people who take Clozaril (clozapine), especially for people who are male, 40-49 old, have been taking the drug for < 1 month also take Valproate Sodium, and have Schizophrenia, paranoid type.

The phase IV clinical study analyzes which people have Left ventricular failure when taking Clozaril. It is created by eHealthMe based on reports of 64,938 people who have side effects when taking Clozaril from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Left ventricular failure?

Left ventricular failure (left ventricle fails to contract forcefully) is found to be associated with 594 drugs and 665 conditions by eHealthMe. Check the latest studies of Left ventricular failure.

On Jul, 15, 2026

64,938 people reported to have side effects when taking Clozaril.
Among them, 62 people (0.1%) have Left ventricular failure.

Could Clozaril cause Left ventricular failure?

Among these 62 people:

How long have people been on Clozaril when they have Left ventricular failure? *

  • < 1 month: 54.55 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 9.09 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 18.18 %
  • 10+ years: 18.18 %

What is the gender of people who have Left ventricular failure when taking Clozaril? *

  • female: 24.59 %
  • male: 75.41 %

What is the age of people who have Left ventricular failure when taking Clozaril? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 20.41 %
  • 30-39: 20.41 %
  • 40-49: 26.53 %
  • 50-59: 18.37 %
  • 60+: 14.29 %

What are other drugs people take besides Clozaril? *

  1. Amisulpride: 5 people, 8.06%
  2. Voltaren: 5 people, 8.06%
  3. Valproate Sodium: 5 people, 8.06%
  4. Lamictal: 4 people, 6.45%
  5. Lansoprazole: 3 people, 4.84%
  6. Gaviscon: 3 people, 4.84%
  7. Zyprexa: 3 people, 4.84%
  8. Valium: 3 people, 4.84%
  9. Prednisolone: 2 people, 3.23%
  10. Diazepam: 2 people, 3.23%

What are other side effects people have besides Left ventricular failure? *

  1. Fever: 13 people, 20.97%
  2. Cardiomyopathy (weakening of the heart muscle): 10 people, 16.13%
  3. Malaise (a feeling of general discomfort or uneasiness): 10 people, 16.13%
  4. Hypotension (abnormally low blood pressure): 10 people, 16.13%
  5. Dyspnea (difficult or laboured breathing): 9 people, 14.52%
  6. Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 8 people, 12.90%
  7. Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 7 people, 11.29%
  8. C-Reactive Protein Increased: 7 people, 11.29%
  9. Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 6 people, 9.68%
  10. Ejection Fraction Abnormal (abnormality in percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat): 6 people, 9.68%

What are the existing conditions these people have? *

  1. Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 4 people, 6.45%
  2. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 3.23%
  3. Insomnia (sleeplessness): 2 people, 3.23%
  4. High Blood Cholesterol: 2 people, 3.23%
  5. Endometrial Cancer: 1 person, 1.61%
  6. Agitation (state of anxiety or nervous excitement): 1 person, 1.61%
  7. Asthma: 1 person, 1.61%
  8. Cardiac Failure: 1 person, 1.61%
  9. Constipation: 1 person, 1.61%
  10. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 1.61%

* Approximation only. Some reports may have incomplete information.

Do you take Clozaril and have Left ventricular failure?

- Check whether Left ventricular failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozaril:

Left ventricular failure treatments and more:

How severe was Left ventricular failure and when was it recovered:

Expand to all the drugs that have ingredients of clozapine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clozaril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Left ventricular failure:

Browse all the conditions that are associated with Left ventricular failure:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozaril) and Clozaril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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