Opsumit and Otezla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Opsumit (macitentan) and Otezla (apremilast). Common drug interactions include encephalitis viral among females and tuberculosis among males.

The phase IV clinical study analyzes what interactions people have when they take Opsumit and Otezla. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

On Jul, 17, 2026

19 people who take Opsumit and Otezla together, and have interactions are studied.

What are the common drug interactions of Opsumit and Otezla, by gender? *:

female:

Encephalitis viral (inflammation of the brain due to viral infection)
Immunosuppression
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Weight decreased
Abdominal pain
Back pain
Depressed level of consciousness
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)

male:

Tuberculosis (a bacterial infection by mycobacterium tuberculosis)

What are the common drug interactions of Opsumit and Otezla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Immunosuppression
Pneumonia
Headache (pain in head)

50-59:

Depressed level of consciousness
Respiratory syncytial virus infection (viral disease of respiratory system)

60+:

Encephalitis viral (inflammation of the brain due to viral infection)
Pain
Gait disturbance
Haemorrhage (bleeding)
Head injury
Hypoaesthesia (reduced sense of touch or sensation)
Lower respiratory tract infection
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle rupture (tear in muscle)
Psoriasis (immune-mediated disease that affects the skin)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 36.84%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 26.32%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 21.05%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 10.53%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 2 people, 10.53%
Embolism Venous (embolus may pass into the arterial system): 1 person, 5.26%
Diabetes: 1 person, 5.26%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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