Optimark and Catapres-tts-1 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Optimark (gadoversetamide) and Catapres-tts-1 (clonidine). Common drug interactions include nephrogenic systemic fibrosis among females.

The phase IV clinical study analyzes what interactions people have when they take Optimark and Catapres-tts-1. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

What is Catapres-tts-1?

Catapres-tts-1 has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 2,047 Catapres-tts-1 users. Check the latest studies of Catapres-tts-1.



On Jul, 12, 2026

11 people who take Optimark and Catapres-tts-1 together, and have interactions are studied.

Optimark and Catapres-tts-1 drug interactions.

What are the common drug interactions of Optimark and Catapres-Tts-1, by gender? *:

female:

  1. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
  2. Pain
  3. Pneumonia
  4. Urinary tract infection
  5. Vomiting
  6. Fluid retention (an abnormal accumulation of fluid in the blood)
  7. Gait disturbance
  8. Rash
  9. Skin hypopigmentation (loss of skin colour)
  10. Skin plaque (red, scaly patches to appear on the skin)

male:

n/a

What are the common drug interactions of Optimark and Catapres-Tts-1, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Constipation
  3. Decreased appetite
  4. Diarrhoea
  5. Dizziness
  6. Excoriation (to tear or wear off the skin of)
  7. Haemorrhoids (a swollen vein or group of veins in the region of the anus)
  8. Hypotension (abnormally low blood pressure)
  9. Insomnia (sleeplessness)
  10. Lethargy (tiredness)

50-59:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Dry skin
  4. Emotional distress
  5. Erythema (redness of the skin)
  6. Excoriation (to tear or wear off the skin of)
  7. Gait disturbance
  8. Injury
  9. Joint range of motion decreased (disease of joint movement)
  10. Joint stiffness

60+:

  1. Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
  2. Dry skin
  3. Skin plaque (red, scaly patches to appear on the skin)
  4. Skin tightness
  5. Swelling
  6. Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
  7. Chest pain
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  9. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  10. Encephalomalacia (localized softening of the brain substance, due to haemorrhage or inflammation)

What are the existing conditions these people have? *

  1. Vaginal Infection: 2 people, 18.18%
  2. Stress And Anxiety: 2 people, 18.18%
  3. Nuclear Magnetic Resonance Imaging Brain: 2 people, 18.18%
  4. Nuclear Magnetic Resonance Imaging Abdominal: 2 people, 18.18%
  5. Blood Phosphorus Increased: 2 people, 18.18%
  6. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 9.09%
  7. Psoriasis (immune-mediated disease that affects the skin): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Optimark and Catapres-tts-1:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Optimark:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Catapres-tts-1:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Optimark and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Catapres-tts-1 and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on gadoversetamide and clonidine (the active ingredients of Optimark and Catapres-tts-1, respectively), and Optimark and Catapres-tts-1 (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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