Optimark and Isordil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Optimark (gadoversetamide) and Isordil (isosorbide dinitrate). Common drug interactions include splenomegaly among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Optimark and Isordil. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

What is Isordil?

Isordil has active ingredients of isosorbide dinitrate. eHealthMe is studying from 3,022 Isordil users. Check the latest studies of Isordil.

On Aug, 04, 2026

16 people who take Optimark and Isordil together, and have interactions are studied.

What are the common drug interactions of Optimark and Isordil, by gender? *:

female:

Splenomegaly (enlargement of spleen)
Staphylococcal infection (an infection with staphylococcus bacteria)
Thrombocytopenia (decrease of platelets in blood)
Urinary tract infection fungal
Back pain
Duodenitis (inflammation of the duodenum)
Face oedema (swelling of face)
Ataxia (loss of full control of bodily movements)
Deformity (disfigurement)
Dysphagia (a condition in which swallowing is difficult or painful)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Oedema peripheral (superficial swelling)
Pain
Pain of skin
Scar
Skin exfoliation (removal of the oldest dead skin cells)
Skin fibrosis (fibrous tissue formation on skin)
Deformity (disfigurement)
Emotional distress

What are the common drug interactions of Optimark and Isordil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Clubbing (deformity of the fingers and fingernails)
Emotional distress
Eustachian tube dysfunction (eustachian tube problems like clearing the ears when flying, suffering infection, and recurring ear infection)
Gastroenteritis (inflammation of stomach and intestine)
Haematemesis (vomiting of blood)
Haematoma (collection of blood outside the blood vessels)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperkalaemia (damage to or disease of the kidney)

60+:

n/a

What are the existing conditions these people have? *

Diabetes: 10 people, 62.50%
Nuclear Magnetic Resonance Imaging Brain: 9 people, 56.25%
Anaemia (lack of blood): 8 people, 50.00%
High Blood Pressure: 6 people, 37.50%
Pain: 5 people, 31.25%
Chest Pain: 5 people, 31.25%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 25.00%
Sleep Disorder: 2 people, 12.50%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 12.50%
Neuralgia (pain in one or more nerves): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Optimark and Isordil?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously