Optimark and Nexium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Optimark (gadoversetamide) and Nexium (esomeprazole magnesium). Common drug interactions include oedema peripheral among females and nephrogenic systemic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Optimark and Nexium. It is created by eHealthMe based on reports of 96 people who take the same drugs from the FDA, and is updated regularly.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,678 Nexium users. Check the latest studies of Nexium.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

96 people who take Optimark and Nexium together, and have interactions are studied.

What are the common drug interactions of Optimark and Nexium, by gender? *:

female:

Oedema peripheral (superficial swelling)
Scar
Pruritus (severe itching of the skin)
Hypotension (abnormally low blood pressure)
Mobility decreased (ability to move is reduced)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Asthenia (weakness)
Dry skin
Dyspnoea (difficult or laboured respiration)
Deformity (disfigurement)

male:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Oedema (fluid collection in tissue)
Rash
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Fibromyalgia (a long-term condition which causes pain all over the body)
Hyperthyroidism (over activity of the thyroid gland)
Intervertebral disc degeneration (spinal disc degeneration)
Lacunar infarction (a type of stroke)

What are the common drug interactions of Optimark and Nexium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Activities of daily living impaired
Chest pain
Diaphragmatic disorder
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Gastritis (inflammation of stomach)
Pericarditis constrictive (inflammation of the pericardium-constrictive)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

30-39:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Arteriovenous fistula occlusion
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial thrombosis (blood clot that develops in an artery)
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Device related infection
Dyspnoea (difficult or laboured respiration)

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Skin hypertrophy (skin cells enlarges)
Skin induration (an abnormally hard spot or area on the skin)
Arthralgia (joint pain)
Skin tightness
Deformity (disfigurement)
Joint range of motion decreased (disease of joint movement)
Oedema peripheral (superficial swelling)
Scar

50-59:

General physical health deterioration (weak health status)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Medical device complication
Mitral valve incompetence (inefficient heart valve)
Pain of skin
Restlessness (not able to rest)
Alopecia (absence of hair from areas of the body)
Burning sensation
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dry skin

60+:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Mobility decreased (ability to move is reduced)
Skin tightness
Oedema (fluid collection in tissue)
Skin induration (an abnormally hard spot or area on the skin)
Abdominal abscess (collection of pus in abdomen)
Abdominal pain
Anxiety
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Emotional distress

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 31 people, 32.29%
High Blood Cholesterol: 16 people, 16.67%
Diabetes: 15 people, 15.62%
High Blood Pressure: 14 people, 14.58%
Pain: 14 people, 14.58%
Anaemia (lack of blood): 10 people, 10.42%
Thyroid Diseases: 9 people, 9.38%
Sleep Disorder: 9 people, 9.38%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 8.33%
Neuralgia (pain in one or more nerves): 7 people, 7.29%

* Approximation only. Some reports may have incomplete information.

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