Optimark and Seroquel drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Optimark (gadoversetamide) and Seroquel (quetiapine fumarate). Common drug interactions include anxiety among females and nephrogenic systemic fibrosis among males.
The phase IV clinical study analyzes what interactions people have when they take Optimark and Seroquel. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.
What is Optimark?
Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.
What is Seroquel?
Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.
21 people who take Optimark and Seroquel together, and have interactions are studied.

What are the common drug interactions of Optimark and Seroquel, by gender? *:
female:
- Anxiety
- Pain
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Injury
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Arthralgia (joint pain)
- Deformity (disfigurement)
- Dry skin
- Joint contracture (a permanent shortening of a muscle or joint)
- Pruritus (severe itching of the skin)
male:
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Abdominal hernia
- Hepatic neoplasm malignant (liver cancer)
- Osteomyelitis (infection of bone)
- Pleural effusion (water on the lungs)
- Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
- Renal cyst (kidney cyst)
- Renal failure (kidney dysfunction)
- Respiratory failure (inadequate gas exchange by the respiratory system)
- Spinal osteoarthritis (joint cartilage loss in spine)
What are the common drug interactions of Optimark and Seroquel, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Anxiety
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Pain
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Arthralgia (joint pain)
- Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
- Deformity (disfigurement)
- Dry skin
- Endocardial fibrosis (cardiac fibrosis refers to an abnormal thickening of the heart valves)
- Excoriation (to tear or wear off the skin of)
50-59:
- Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
- Abdominal hernia
- Hepatic neoplasm malignant (liver cancer)
- Osteomyelitis (infection of bone)
- Pleural effusion (water on the lungs)
- Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)
- Renal cyst (kidney cyst)
- Renal failure (kidney dysfunction)
- Respiratory failure (inadequate gas exchange by the respiratory system)
- Spinal osteoarthritis (joint cartilage loss in spine)
60+:
n/a
What are the existing conditions these people have? *
- Nuclear Magnetic Resonance Imaging Brain: 3 people, 14.29%
* Approximation only. Some reports may have incomplete information.
Do you take Optimark and Seroquel?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Optimark and Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Optimark:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Seroquel:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Optimark and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Seroquel and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
- Mati?, K., & Pele?, A. M. , "Drug-induced toxic hepatitis associated with the combination of quetiapine and fluphenazine: A case report", The European Journal of Psychiatry, 2018 Jan .
- Shah Z, Londhe V, "Influence of various media on the dissolution profiles of immediate-release quetiapine tablets in India", Dissolution Technologies, 2016 Feb .
How the study uses the data?
The study uses data from the FDA. It is based on gadoversetamide and quetiapine fumarate (the active ingredients of Optimark and Seroquel, respectively), and Optimark and Seroquel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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