Oracea and Ritalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oracea (doxycycline) and Ritalin (methylphenidate hydrochloride). Common drug interactions include gastrooesophageal reflux disease among females and abscess among males.

The phase IV clinical study analyzes what interactions people have when they take Oracea and Ritalin. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Oracea?

Oracea has active ingredients of doxycycline. It is often used in rosacea. eHealthMe is studying from 1,272 Oracea users. Check the latest studies of Oracea.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.



On Jul, 18, 2026

21 people who take Oracea and Ritalin together, and have interactions are studied.

Oracea and Ritalin drug interactions.

What are the common drug interactions of Oracea and Ritalin, by gender? *:

female:

  1. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  2. Fatigue (feeling of tiredness)
  3. Csf pressure increased
  4. Neuralgia (pain in one or more nerves)
  5. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  6. Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
  7. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  8. Nausea (feeling of having an urge to vomit)
  9. Weight increased
  10. Anxiety

male:

  1. Abscess (pus)
  2. Anxiety
  3. Nervousness
  4. Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
  5. Oedema (fluid collection in tissue)
  6. Pain
  7. Pharyngitis (inflammation of the pharynx, causing a sore throat)
  8. Rash
  9. Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
  10. Skin infection

What are the common drug interactions of Oracea and Ritalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Abscess (pus)
  2. Anxiety
  3. Blood lactate dehydrogenase increased
  4. Discomfort
  5. Dizziness
  6. Dyspnoea (difficult or laboured respiration)
  7. Erythema (redness of the skin)
  8. Fatigue (feeling of tiredness)
  9. Furuncle (infection of the hair follicle)
  10. Hypersensitivity

30-39:

  1. Fatigue (feeling of tiredness)
  2. Dry skin
  3. Eye pruritus (eye itching)
  4. Photophobia (extreme sensitivity to light)
  5. Photosensitivity reaction

40-49:

  1. Dizziness
  2. Nausea (feeling of having an urge to vomit)
  3. Stress
  4. Tinnitus (a ringing in the ears)
  5. Vomiting
  6. Activities of daily living impaired
  7. Anxiety
  8. Asthenia (weakness)
  9. Burning sensation
  10. Conjunctivitis (pink eye)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 71.43%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 28.57%
  3. Skin Wrinkling (wrinkle on skin): 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Oracea and Ritalin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Oracea and Ritalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oracea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ritalin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Oracea and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ritalin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on doxycycline and methylphenidate hydrochloride (the active ingredients of Oracea and Ritalin, respectively), and Oracea and Ritalin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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