Ortho-est and Provera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ortho-est (estropipate) and Provera (medroxyprogesterone acetate). Common drug interactions include breast cancer among females and breast cancer female among males.

The phase IV clinical study analyzes what interactions people have when they take Ortho-est and Provera. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Ortho-est?

Ortho-est has active ingredients of estropipate. eHealthMe is studying from 52 Ortho-est users. Check the latest studies of Ortho-est.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

On Jul, 13, 2026

24 people who take Ortho-est and Provera together, and have interactions are studied.

Ortho-est and Provera drug interactions.

What are the common drug interactions of Ortho-Est and Provera, by gender? *:

female:

Breast cancer
Breast cancer female
Abdominal pain
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Menstruation delayed (late menstruation cycle)
Thrombosis (formation of a blood clot inside a blood vessel)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hyperhidrosis (abnormally increased sweating)
Vomiting
Death

male:

Breast cancer female
Abdominal hernia
Breast cancer
Chondropathy (disease of the cartilage)
Deformity (disfigurement)
Depression
Dyspepsia (indigestion)
Haematemesis (vomiting of blood)
Hot flush (sudden feelings of heat)
Injury

What are the common drug interactions of Ortho-Est and Provera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Breast cancer female
Menstruation delayed (late menstruation cycle)

40-49:

Breast cancer female
Abdominal hernia
Chest pain
Hyperhidrosis (abnormally increased sweating)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Weight increased

50-59:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Thrombosis (formation of a blood clot inside a blood vessel)
Anxiety
Atrophic vulvovaginitis (inflammation of the vulva)
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Breast cancer female
Chondropathy (disease of the cartilage)
Death
Deformity (disfigurement)
Depression

60+:

Breast cancer female
Ovarian cancer (cancer of ovary)
Haemorrhage (bleeding)
Abdominal pain
Breast cancer
Defaecation urgency (a sudden compelling urge to defecate)
Dysuria (painful or difficult urination)
Frequent bowel movements
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)

What are the existing conditions these people have? *

Menopause (end of monthly cycles in women): 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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