Ortho evra and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ortho evra (ethinyl estradiol; norelgestromin) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include menstruation irregular among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Ortho evra and Macrobid. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Ortho evra?

Ortho evra has active ingredients of ethinyl estradiol; norelgestromin. It is often used in birth control. eHealthMe is studying from 29,275 Ortho evra users. Check the latest studies of Ortho evra.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 20, 2026

37 people who take Ortho evra and Macrobid together, and have interactions are studied.

Ortho evra and Macrobid drug interactions.

What are the common drug interactions of Ortho Evra and Macrobid, by gender? *:

female:

Menstruation irregular
Nausea (feeling of having an urge to vomit)
Scar
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Abdominal pain
Abdominal pain lower
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Application site pustules (small bumps on the skin that fill with fluid or pus at application site)

male:

Cardiac disorder
Premature baby

What are the common drug interactions of Ortho Evra and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Drug exposure during pregnancy
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Pulmonary embolism (blockage of the main artery of the lung)
Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)
Vaginitis bacterial (inflammation of the vagina caused by bacterial infection)

20-29:

Metrorrhagia (uterine bleeding at irregular intervals)
Nausea (feeling of having an urge to vomit)
Scar
Abdominal pain
Abdominal pain lower
Abdominal pain upper
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Anxiety
Application site pustules (small bumps on the skin that fill with fluid or pus at application site)
Breast disorder

30-39:

Premenstrual syndrome
Urticaria generalised (rash of round, red welts on the skin that itch intensely- generalised)
Venous thrombosis (blood clot (thrombus) that forms within a vein)
Weight increased
Drug exposure during pregnancy
Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)
Thrombophlebitis superficial (swelling (inflammation) of a superficial vein caused by a blood clot)
Fungal infection
Injury
Metrorrhagia (uterine bleeding at irregular intervals)

40-49:

Menstruation irregular
Metrorrhagia (uterine bleeding at irregular intervals)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Pain: 7 people, 18.92%

* Approximation only. Some reports may have incomplete information.

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