Ortho tri-cyclen and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ortho tri-cyclen (ethinyl estradiol; norgestimate) and Cymbalta (duloxetine hydrochloride). Common drug interactions include nausea among females.

The phase IV clinical study analyzes what interactions people have when they take Ortho tri-cyclen and Cymbalta. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Ortho tri-cyclen?

Ortho tri-cyclen has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 5,699 Ortho tri-cyclen users. Check the latest studies of Ortho tri-cyclen.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

On Jul, 19, 2026

47 people who take Ortho tri-cyclen and Cymbalta together, and have interactions are studied.

Ortho tri-cyclen and Cymbalta drug interactions.

What are the common drug interactions of Ortho Tri-Cyclen and Cymbalta, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Feeling hot
Vomiting
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Cholecystitis (infection of gallbladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hypoaesthesia (reduced sense of touch or sensation)

male:

n/a

What are the common drug interactions of Ortho Tri-Cyclen and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Fatigue (feeling of tiredness)
Feeling hot
Gastric disorder (disease of stomach)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Headache (pain in head)
Hyperglycaemia (high blood sugar)
Hyperinsulinaemia (excess levels of insulin circulating in the blood)
Menstrual disorder (disease of menstrual cycle)

20-29:

Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Pancreatitis acute (sudden inflammation of pancreas)
Adverse drug reaction
Cholecystitis (infection of gallbladder)
Diarrhoea
Fatigue (feeling of tiredness)
Pain
Abdominal pain
Abdominal pain upper

30-39:

Blood pressure increased
Blood sodium decreased
Chills (felling of cold)
Feeling hot
Muscle spasms (muscle contraction)
Alanine aminotransferase increased
Night sweats (sweating in night)
Abdominal pain
Abdominal pain upper
Arthralgia (joint pain)

40-49:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Abdominal pain upper
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Herpes simplex (herpes simplex is a common viral infection)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pain
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Activities of daily living impaired

50-59:

Fatigue (feeling of tiredness)
Abdominal pain
Brain stem stroke (rapid loss of brain function due to disturbance in the blood supply to the brain)
Candidiasis (candidiasis or thrush is a fungal infection)
Carotid artery disease
Carotid artery stenosis (narrowing of carotid artery)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

60+:

n/a

What are the existing conditions these people have? *

Stress And Anxiety: 7 people, 14.89%
Pain: 5 people, 10.64%
Nausea (feeling of having an urge to vomit): 5 people, 10.64%
Bipolar Disorder (mood disorder): 5 people, 10.64%
Insomnia (sleeplessness): 4 people, 8.51%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 8.51%
Chest Pain: 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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