Allopurinol and Raynaud's phenomenon - a phase IV clinical study of FDA data

Summary:

Raynaud's phenomenon is reported as a side effect among people who take Allopurinol (allopurinol), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Amlodipine, and have Pain.

The phase IV clinical study analyzes which people have Raynaud's phenomenon when taking Allopurinol. It is created by eHealthMe based on reports of 188,106 people who have side effects when taking Allopurinol from the FDA, and is updated regularly.

What is Allopurinol?

Allopurinol has active ingredients of allopurinol. It is often used in gout. eHealthMe is studying from 190,868 Allopurinol users. Check the latest studies of Allopurinol.

What is Raynaud's phenomenon?

Raynaud's phenomenon (discoloration of the fingers, toes, and occasionally other areas) is found to be associated with 634 drugs and 995 conditions by eHealthMe. Check the latest studies of Raynaud's phenomenon.

On Jul, 19, 2026

188,106 people reported to have side effects when taking Allopurinol.
Among them, 54 people (0.03%) have Raynaud's phenomenon.

Could Allopurinol cause Raynaud's phenomenon?

Among these 54 people:

How long have people been on Allopurinol when they have Raynaud's phenomenon? *

What is the gender of people who have Raynaud's phenomenon when taking Allopurinol? *

female: 14.29 %
male: 85.71 %

What is the age of people who have Raynaud's phenomenon when taking Allopurinol? *

What are other drugs people take besides Allopurinol? *

What are other side effects people have besides Raynaud's phenomenon? *

Pain: 17 people, 31.48%
Rashes (redness): 11 people, 20.37%
Hypoaesthesia (reduced sense of touch or sensation): 10 people, 18.52%
Dyspnea (difficult or laboured breathing): 10 people, 18.52%
Arthropathy: 9 people, 16.67%
Joint Swelling: 9 people, 16.67%
Muscle Spasms (muscle contraction): 8 people, 14.81%
Joint Pain: 8 people, 14.81%
Fatigue (feeling of tiredness): 8 people, 14.81%
Drug Ineffective: 7 people, 12.96%

What are the existing conditions these people have? *

Pain: 10 people, 18.52%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 6 people, 11.11%
High Blood Pressure: 5 people, 9.26%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 9.26%
Psoriasis (immune-mediated disease that affects the skin): 5 people, 9.26%
Blood Phosphorus Increased: 5 people, 9.26%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 9.26%
Nuclear Magnetic Resonance Imaging Brain: 5 people, 9.26%
Blood Uric Acid Increased: 4 people, 7.41%
Depression: 4 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Allopurinol and have Raynaud's phenomenon?

- Check whether Raynaud's phenomenon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Allopurinol:

Allopurinol (190,868 reports)

Browse all side effects of Allopurinol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (634 drugs)

Browse all the conditions that are associated with Raynaud's phenomenon:

Raynaud's phenomenon (995 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on allopurinol (the active ingredients of Allopurinol) and Allopurinol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.