Osphena and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Osphena (ospemifene) and Zantac (ranitidine hydrochloride). Common drug interactions include drug ineffective among females.

The phase IV clinical study analyzes what interactions people have when they take Osphena and Zantac. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Osphena?

Osphena has active ingredients of ospemifene. eHealthMe is studying from 2,762 Osphena users. Check the latest studies of Osphena.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Jul, 11, 2026

26 people who take Osphena and Zantac together, and have interactions are studied.

What are the common drug interactions of Osphena and Zantac, by gender? *:

female:

Drug ineffective
Ligament sprain (ligament stretched)
Foot fracture
Infusion site bruising
Multiple allergies (allergy to multiple agents)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Restless legs syndrome (a powerful urge to move your legs)
Scar
Sinusitis (inflammation of sinus)

male:

n/a

What are the common drug interactions of Osphena and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hepatic enzyme increased

40-49:

Abdominal pain upper
Back pain
Chest pain
Diarrhoea
Dysmenorrhoea (painful menstruation)
Dysphonia (speech disorder attributable to a disorder of phonation)
Hyperaesthesia
Migraine (headache)
Pain in extremity
Vaginal haemorrhage (vaginal bleeding)

50-59:

Chest discomfort

60+:

Drug ineffective
Abdominal pain lower
Multiple allergies (allergy to multiple agents)
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Restless legs syndrome (a powerful urge to move your legs)
Scar
Sinusitis (inflammation of sinus)
Sneezing
Therapeutic response unexpected

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 34.62%
Sexual Intercourse - Painful: 6 people, 23.08%
Vulvovaginal Dryness: 5 people, 19.23%
Primary Immunodeficiency Syndrome: 5 people, 19.23%
Visual Impairment: 3 people, 11.54%
Vulvovaginal Injury: 2 people, 7.69%
Pain: 2 people, 7.69%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 7.69%
Cardiac Disorder: 2 people, 7.69%
Blindness: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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