Otezla and Methyldopa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Otezla (apremilast) and Methyldopa (methyldopa). Common drug interactions include nausea among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Otezla and Methyldopa. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Otezla?

Otezla has active ingredients of apremilast. It is often used in psoriatic arthritis. eHealthMe is studying from 146,254 Otezla users. Check the latest studies of Otezla.

What is Methyldopa?

Methyldopa has active ingredients of methyldopa. It is often used in high blood pressure. eHealthMe is studying from 6,475 Methyldopa users. Check the latest studies of Methyldopa.

On Jul, 18, 2026

11 people who take Otezla and Methyldopa together, and have interactions are studied.

Otezla and Methyldopa drug interactions.

What are the common drug interactions of Otezla and Methyldopa, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Pain
Type 2 diabetes mellitus
Maternal exposure during pregnancy (use of substance during pregnancy)
Delivery
Drug ineffective
Malaise (a feeling of general discomfort or uneasiness)
Abdominal discomfort
Gestational diabetes (diabetes in pregnancy)
Headache (pain in head)

male:

Diarrhoea
Malaise (a feeling of general discomfort or uneasiness)
Psoriasis (immune-mediated disease that affects the skin)

What are the common drug interactions of Otezla and Methyldopa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Gestational diabetes (diabetes in pregnancy)
Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

Delivery
Malaise (a feeling of general discomfort or uneasiness)
Maternal exposure during pregnancy (use of substance during pregnancy)
Abdominal discomfort
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Pain

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 8 people, 72.73%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 36.36%
Type 2 Diabetes: 1 person, 9.09%
Headache (pain in head): 1 person, 9.09%
Binge Eating (pattern of disordered eating which consists of episodes of uncontrollable eating): 1 person, 9.09%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 9.09%
Diabetes: 1 person, 9.09%
Gastric Ph Decreased: 1 person, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%
Hypersensitivity: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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