Oxbryta and Exjade drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxbryta (voxelotor) and Exjade (deferasirox). Common drug interactions include diarrhoea among females and weight decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Oxbryta and Exjade. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Oxbryta?

Oxbryta has active ingredients of voxelotor. eHealthMe is studying from 24,969 Oxbryta users. Check the latest studies of Oxbryta.

What is Exjade?

Exjade has active ingredients of deferasirox. It is often used in iron overload. eHealthMe is studying from 29,456 Exjade users. Check the latest studies of Exjade.

On Jul, 26, 2026

39 people who take Oxbryta and Exjade together, and have interactions are studied.

What are the common drug interactions of Oxbryta and Exjade, by gender? *:

female:

Diarrhoea
Nausea (feeling of having an urge to vomit)
Decreased appetite
Vomiting
Abdominal discomfort
Headache (pain in head)
Haemoglobin decreased
Asthenia (weakness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Oxygen saturation decreased

male:

Weight decreased
Asthenia (weakness)
Lung disorder (lung disease)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pneumonia
Pyrexia (fever)
Renal failure (kidney dysfunction)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Reticulocytopenia (an abnormal decrease of reticulocytes in the body)
Rhinorrhoea (watery mucus discharge from the nose)

What are the common drug interactions of Oxbryta and Exjade, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pyrexia (fever)
Abdominal pain
Drug ineffective
Osteomyelitis (infection of bone)
Rash
Vomiting

20-29:

n/a

30-39:

Diarrhoea
Abdominal discomfort
Abdominal distension
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haemoglobin decreased
Oxygen saturation decreased
Surgery
Weight increased
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Pain

40-49:

Pneumonia
Acute chest syndrome (acute chest pain, fever and difficulty breathing)
Acute hepatic failure
Acute respiratory failure
Atrioventricular block second degree (heart block second degree)
Bradycardia (abnormally slow heart action)
Cardiac arrest
Chronic kidney disease
Death
Diarrhoea

50-59:

Asthenia (weakness)
Diarrhoea
Back pain
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Lung disorder (lung disease)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

60+:

Peripheral swelling

What are the existing conditions these people have? *

Pain: 6 people, 15.38%
Thyroid Diseases: 3 people, 7.69%
Haemochromatosis (body to absorb more iron than usual from food): 3 people, 7.69%
Stress And Anxiety: 2 people, 5.13%
Sleep Disorder: 2 people, 5.13%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 5.13%
Irritable Bowel Syndrome: 2 people, 5.13%
Insomnia (sleeplessness): 2 people, 5.13%
Inflammation: 2 people, 5.13%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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