Oxycet and Benadryl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycet (acetaminophen; oxycodone hydrochloride) and Benadryl (diphenhydramine hydrochloride). Common drug interactions include chest pain among females and incision site infection among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycet and Benadryl. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycet?

Oxycet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 492 Oxycet users. Check the latest studies of Oxycet.

What is Benadryl?

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. eHealthMe is studying from 104,955 Benadryl users. Check the latest studies of Benadryl.

On Aug, 11, 2026

11 people who take Oxycet and Benadryl together, and have interactions are studied.

What are the common drug interactions of Oxycet and Benadryl, by gender? *:

female:

Chest pain
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coeliac artery compression syndrome (abdominal pain related to compression of the celiac artery)
Constipation
Cough
Cystitis (inflammation of the wall of the bladder)
Drug dependence
Dyspnoea (difficult or laboured respiration)
Escherichia urinary tract infection (urinary tract infection by escherichia coli)

male:

Incision site infection (infection at incision site)
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Shoulder operation

What are the common drug interactions of Oxycet and Benadryl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cystitis (inflammation of the wall of the bladder)
Dizziness
Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Pancreatitis (inflammation of pancreas)
Vomiting

20-29:

Chest discomfort
Chest pain
Cough
Dizziness
Dyspnoea (difficult or laboured respiration)
Loss of consciousness
Neoplasm malignant (cancer tumour)
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)

30-39:

Acute respiratory distress syndrome
Coeliac artery compression syndrome (abdominal pain related to compression of the celiac artery)
Constipation
Drug dependence
Hepatic necrosis (large portions of liver die off due to severe liver disease)
Pneumonia
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

40-49:

n/a

50-59:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Rectocele (a bulging of the front wall of the rectum into the back wall of the vagina)
Renal cyst (kidney cyst)

60+:

Enteritis infectious (infection with feline parvovirus (fpv), also known as feline panleucopenia virus)
Incision site infection (infection at incision site)
Intestinal obstruction
Nasopharyngitis (inflammation of the nasopharynx)
Oropharyngeal pain
Shoulder operation

What are the existing conditions these people have? *

Birth Control: 7 people, 63.64%
Itching: 4 people, 36.36%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 36.36%
Stress And Anxiety: 2 people, 18.18%
Sleep Disorder: 2 people, 18.18%
Anaemia (lack of blood): 2 people, 18.18%
Analgesia: 2 people, 18.18%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 18.18%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 18.18%
Constipation: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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