Oxycodone and acetaminophen and Robitussin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride) and Robitussin (guaifenesin). Common drug interactions include gait disturbance among females and cluster headache among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and acetaminophen and Robitussin. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Robitussin?

Robitussin has active ingredients of guaifenesin. eHealthMe is studying from 3,532 Robitussin users. Check the latest studies of Robitussin.

On Jul, 12, 2026

32 people who take Oxycodone and acetaminophen and Robitussin together, and have interactions are studied.

Oxycodone and acetaminophen and Robitussin drug interactions.

What are the common drug interactions of Oxycodone And Acetaminophen and Robitussin, by gender? *:

female:

Gait disturbance
Dyspnoea at rest (difficult or laboured breathing during rest)
Dysuria (painful or difficult urination)
Nasopharyngitis (inflammation of the nasopharynx)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Productive cough
Respiratory tract infection
Upper limb fracture
Diarrhoea
Fatigue (feeling of tiredness)

male:

Cluster headache (one-sided head pain with tearing)
Craniocerebral injury (injury to cranium and brain)
Chronic kidney disease
Emotional distress
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Limb injury
Mobility decreased (ability to move is reduced)
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Renal cyst (kidney cyst)

What are the common drug interactions of Oxycodone And Acetaminophen and Robitussin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Chronic kidney disease
Emotional distress
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mobility decreased (ability to move is reduced)
Renal cyst (kidney cyst)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

n/a

50-59:

Fatigue (feeling of tiredness)
Abdominal discomfort
Anaemia (lack of blood)
Bone pain
Chronic kidney disease
Cough
Diarrhoea
Disease progression
Dysarthria (speech disorder)
Dyspepsia (indigestion)

60+:

Dyspnoea at rest (difficult or laboured breathing during rest)
Dysuria (painful or difficult urination)
Palpitations (feelings or sensations that your heart is pounding or racing)
Peripheral swelling
Thrombosis (formation of a blood clot inside a blood vessel)
Arthralgia (joint pain)
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Gastrointestinal infection (infection of stomach and intestine)
Headache (pain in head)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 21.88%
Migraine (headache): 4 people, 12.50%
Dyspnea (difficult or laboured breathing): 4 people, 12.50%
Inflammation: 3 people, 9.38%
Hypersensitivity: 3 people, 9.38%
Hiv Infection: 3 people, 9.38%
Hepatitis B: 3 people, 9.38%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 9.38%
Asthma: 3 people, 9.38%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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