Oxycodone and acetaminophen and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride) and Savella (milnacipran hydrochloride). Common drug interactions include fall among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone and acetaminophen and Savella. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

51 people who take Oxycodone and acetaminophen and Savella together, and have interactions are studied.

Oxycodone and acetaminophen and Savella drug interactions.

What are the common drug interactions of Oxycodone And Acetaminophen and Savella, by gender? *:

female:

Fall
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cerebral haemorrhage (bleeding within the brain)
Concussion (short loss of normal brain function in response to a head injury)
Road traffic accident
Chronic kidney disease
Nausea (feeling of having an urge to vomit)
Surgery

male:

Cardiac disorder
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Penile pain
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Oxycodone And Acetaminophen and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Malaise (a feeling of general discomfort or uneasiness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Cerebral haemorrhage (bleeding within the brain)
Concussion (short loss of normal brain function in response to a head injury)
Migraine (headache)
Road traffic accident

40-49:

Adverse drug reaction
Anaphylactic reaction (serious allergic reaction)
Arthralgia (joint pain)
Asthenia (weakness)
Balance disorder
Burning sensation
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chest pain

50-59:

Headache (pain in head)
Fatigue (feeling of tiredness)
Fall
Muscular weakness (muscle weakness)
Asthenia (weakness)
Confusional state
Dry mouth
Dry skin
Faeces discoloured
Hunger

60+:

Cardiac failure
Death
Pain in extremity
Psychological trauma
Renal impairment (severely reduced kidney function)
Skin ulcer
Weight decreased
Alopecia (absence of hair from areas of the body)
Diarrhoea
Injection site pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 23.53%
Stress And Anxiety: 8 people, 15.69%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 13.73%
Depression: 6 people, 11.76%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 9.80%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 7.84%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 7.84%
Insomnia (sleeplessness): 4 people, 7.84%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 7.84%
High Blood Pressure: 4 people, 7.84%

* Approximation only. Some reports may have incomplete information.

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