Oxycodone hydrochloride and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Oxycodone hydrochloride (oxycodone hydrochloride) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include drug ineffective among females and drug dependence among males.

The phase IV clinical study analyzes what interactions people have when they take Oxycodone hydrochloride and Flexeril. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 11, 2026

78 people who take Oxycodone hydrochloride and Flexeril together, and have interactions are studied.

Oxycodone hydrochloride and Flexeril drug interactions.

What are the common drug interactions of Oxycodone Hydrochloride and Flexeril, by gender? *:

female:

Drug ineffective
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Dyspnoea (difficult or laboured respiration)
Overdose
Rash
Fall
Nephrolithiasis (calculi in the kidneys)
Palpitations (feelings or sensations that your heart is pounding or racing)
Road traffic accident
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)

male:

Drug dependence
Overdose
Headache (pain in head)
Intervertebral disc protrusion (spinal disc protrusion)
Urticaria (rash of round, red welts on the skin that itch intensely)
Depression
Drug ineffective
Fatigue (feeling of tiredness)
Injury
Thrombocytopenia (decrease of platelets in blood)

What are the common drug interactions of Oxycodone Hydrochloride and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dental caries
Dysphagia (a condition in which swallowing is difficult or painful)
Gingivitis (inflammation of gums)
Pyrexia (fever)
Abdominal pain
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anaemia of chronic disease
Anaphylactic reaction (serious allergic reaction)

30-39:

Neck pain
Pain in extremity
Arthralgia (joint pain)
Drug dependence
Headache (pain in head)
Overdose
Weight decreased
Balance disorder
Cardiac disorder
Cardiovascular insufficiency (inadequate functioning of heart)

40-49:

Fatigue (feeling of tiredness)
Chest discomfort
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Hypersensitivity
Lip swelling
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Swelling face
Acute respiratory failure

50-59:

Irritability
Loose tooth
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Neck pain
Pain in extremity
Pathological fracture (broken bone caused by disease)
Rhinorrhoea (watery mucus discharge from the nose)
Sneezing
Tinnitus (a ringing in the ears)
Drug ineffective

60+:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Intervertebral disc protrusion (spinal disc protrusion)
Lymphoedema (localized fluid retention and tissue swelling)
Oedema peripheral (superficial swelling)
Oxygen saturation decreased
Pain in extremity
Respiratory rate decreased (less breathing rate/min)
Skin ulcer

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 15.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.41%

* Approximation only. Some reports may have incomplete information.

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