Ozempic and Truvada drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ozempic (semaglutide) and Truvada (emtricitabine; tenofovir disoproxil fumarate). Common drug interactions include emotional distress among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Ozempic and Truvada. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,762 Ozempic users. Check the latest studies of Ozempic.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

30 people who take Ozempic and Truvada together, and have interactions are studied.

What are the common drug interactions of Ozempic and Truvada, by gender? *:

female:

Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic kidney disease
Osteoporosis (bones weak and more likely to break)
Anxiety
Bone density decreased
Renal impairment (severely reduced kidney function)
Depression
Renal failure (kidney dysfunction)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Foot fracture
Neoplasm malignant (cancer tumour)
Plasma cell myeloma (cancer that begins in plasma cells)
Proteinuria (presence of protein in the urine)
Spinal fracture (fracture in one of vertebrae)
Dyspnoea (difficult or laboured respiration)
Dysuria (painful or difficult urination)
Fatigue (feeling of tiredness)

What are the common drug interactions of Ozempic and Truvada, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease
Emotional distress
Pain
Bone density decreased
Bone pain
Chest pain
Drug resistance (reduction in effectiveness of a drug)
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Osteoporosis (bones weak and more likely to break)
Chronic kidney disease
Osteopenia (a condition where bone mineral density is lower than normal)
Bone density decreased
Fatigue (feeling of tiredness)
Gait disturbance

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Hyperparathyroidism (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium)
Hypokalaemia (low potassium)
Osteopenia (a condition where bone mineral density is lower than normal)
Proteinuria (presence of protein in the urine)
Renal impairment (severely reduced kidney function)
Hand fracture
Joint injury
Ageusia (loss of taste functions of the tongue)

What are the existing conditions these people have? *

Diabetes: 3 people, 10.00%
Urinary Retention (the inability to completely or partially empty the bladder): 2 people, 6.67%
Type 2 Diabetes: 2 people, 6.67%
Prostatomegaly (enlargement of the prostate): 2 people, 6.67%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 6.67%
High Blood Pressure: 2 people, 6.67%
High Blood Cholesterol: 2 people, 6.67%
Heart Attack: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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