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Palbociclib and Paroxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Palbociclib (palbociclib) and Paroxetine (paroxetine hydrochloride). Common drug interactions include abdominal pain among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Palbociclib and Paroxetine. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Palbociclib?

Palbociclib has active ingredients of palbociclib. eHealthMe is studying from 11,622 Palbociclib users. Check the latest studies of Palbociclib.

What is Paroxetine?

Paroxetine has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 65,088 Paroxetine users. Check the latest studies of Paroxetine.

On Jul, 12, 2026

23 people who take Palbociclib and Paroxetine together, and have interactions are studied.

Palbociclib and Paroxetine drug interactions.

What are the common drug interactions of Palbociclib and Paroxetine, by gender? *:

female:

  1. Abdominal pain
  2. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  3. Platelet count decreased
  4. Alanine aminotransferase increased
  5. Neutropenia (an abnormally low number of neutrophils)
  6. Pulmonary embolism (blockage of the main artery of the lung)
  7. Anaemia (lack of blood)
  8. Arrhythmia (irregular heartbeat)
  9. Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
  10. Cardiac failure

male:

  1. Death

What are the common drug interactions of Palbociclib and Paroxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Migraine (headache)
  2. Adverse drug reaction
  3. Drug intolerance (drug sensitivity)

50-59:

  1. Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
  2. Platelet count decreased
  3. White blood cell count decreased

60+:

  1. Abdominal pain
  2. Metastases to bone (cancer spreads to bone)
  3. Pulmonary embolism (blockage of the main artery of the lung)
  4. Anaemia (lack of blood)
  5. Arrhythmia (irregular heartbeat)
  6. Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
  7. Cardiac failure
  8. Death
  9. Rash
  10. Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the existing conditions these people have? *

  1. Breast Cancer: 8 people, 34.78%
  2. Breast Cancer Metastatic: 6 people, 26.09%
  3. Depression: 5 people, 21.74%
  4. Lymphadenitis (inflammation or enlargement of a lymph node): 4 people, 17.39%
  5. High Blood Pressure: 4 people, 17.39%
  6. Type 2 Diabetes: 2 people, 8.70%
  7. Allergic Rhinitis: 2 people, 8.70%
  8. Asthma: 2 people, 8.70%
  9. Back Pain: 2 people, 8.70%
  10. Bladder Cancer: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Palbociclib and Paroxetine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Palbociclib and Paroxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Palbociclib:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Paroxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Palbociclib and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Paroxetine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on palbociclib and paroxetine hydrochloride (the active ingredients of Palbociclib and Paroxetine, respectively), and Palbociclib and Paroxetine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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