Pantoprazole and Periactin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pantoprazole (pantoprazole sodium) and Periactin (cyproheptadine hydrochloride). Common drug interactions include respiratory disorder among females and infective pulmonary exacerbation of cystic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Pantoprazole and Periactin. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Pantoprazole?

Pantoprazole has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 285,165 Pantoprazole users. Check the latest studies of Pantoprazole.

What is Periactin?

Periactin has active ingredients of cyproheptadine hydrochloride. It is often used in migraine. eHealthMe is studying from 2,214 Periactin users. Check the latest studies of Periactin.

On Jul, 15, 2026

32 people who take Pantoprazole and Periactin together, and have interactions are studied.

Pantoprazole and Periactin drug interactions.

What are the common drug interactions of Pantoprazole and Periactin, by gender? *:

female:

Respiratory disorder (respiratory disease)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sensory loss (senses loss)
Septic shock (shock due to blood infection)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tooth abscess (pus formation in tooth)
Unresponsive to stimuli
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Vitamin b12 decreased

male:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Anaemia (lack of blood)
Hunger
Lethargy (tiredness)
Leukocytosis (increased white blood cells)
Occult blood positive
Pemphigoid (tense blisters on the skin)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Septic shock (shock due to blood infection)

What are the common drug interactions of Pantoprazole and Periactin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Acinetobacter infection (infection by group of bacteria commonly found in soil and water)
Diarrhoea
Diarrhoea haemorrhagic (bloody diarrhoea)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematoma (collection of blood outside the blood vessels)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Septic shock (shock due to blood infection)
Tooth abscess (pus formation in tooth)

10-19:

Pulmonary embolism (blockage of the main artery of the lung)
Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Hunger
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

20-29:

Alanine aminotransferase increased
Asthma
Blood albumin increased
Blood alkaline phosphatase increased
Blood folate decreased
Hospitalisation
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vitamin b12 decreased
Weight decreased

30-39:

Vomiting

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Bone density decreased
Depression
Emotional distress
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Renal impairment (severely reduced kidney function)
Sensory loss (senses loss)

50-59:

Chronic kidney disease
Dyspepsia (indigestion)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Metastases to adrenals (cancer spreads to adrenal gland of kidney)

60+:

Nausea (feeling of having an urge to vomit)
Organ failure
Mouth haemorrhage (bleeding from mouth)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Syncope (loss of consciousness with an inability to maintain postural tone)
Thrombosis (formation of a blood clot inside a blood vessel)
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 15.62%
High Blood Pressure: 4 people, 12.50%
Cystic Fibrosis (disease of the secretary glands): 4 people, 12.50%
Pain: 3 people, 9.38%
Hypersensitivity: 3 people, 9.38%
Depression: 3 people, 9.38%
Stress And Anxiety: 2 people, 6.25%
Rickets (softening of bones): 2 people, 6.25%
Neoplasm Malignant (cancer tumour): 2 people, 6.25%
Nausea And Vomiting: 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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